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Patient Expectations and Experiences of Antidepressant Therapy for Major Depressive Disorder: A Qualitative Study

PURPOSE: This qualitative study explored patient perceptions of the most burdensome symptoms of major depressive disorder (MDD), the impact of symptoms on patients’ daily lives, and patient expectations and experiences regarding the timing of onset of antidepressant pharmacotherapy. PATIENTS AND MET...

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Autores principales: Baune, Bernhard T, Florea, Ioana, Ebert, Bjarke, Touya, Maëlys, Ettrup, Anders, Hadi, Monica, Ren, Hongye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476086/
https://www.ncbi.nlm.nih.gov/pubmed/34588779
http://dx.doi.org/10.2147/NDT.S325954
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author Baune, Bernhard T
Florea, Ioana
Ebert, Bjarke
Touya, Maëlys
Ettrup, Anders
Hadi, Monica
Ren, Hongye
author_facet Baune, Bernhard T
Florea, Ioana
Ebert, Bjarke
Touya, Maëlys
Ettrup, Anders
Hadi, Monica
Ren, Hongye
author_sort Baune, Bernhard T
collection PubMed
description PURPOSE: This qualitative study explored patient perceptions of the most burdensome symptoms of major depressive disorder (MDD), the impact of symptoms on patients’ daily lives, and patient expectations and experiences regarding the timing of onset of antidepressant pharmacotherapy. PATIENTS AND METHODS: Data were collected through facilitated, patient focus-group sessions in the USA between May and June 2019. Participants were adults with confirmed MDD who reported a major depressive episode within the past 2 years, for which they had received pharmacologic treatment for ≥6 weeks. The semi-structured discussion focused on the key topics of bothersome symptoms of MDD, the impact of symptoms on quality of life, and the effects of antidepressant treatment. Interviews were audio-recorded; findings were summarized using a content-analysis approach. RESULTS: Five focus-group sessions were undertaken, involving a total of 29 patients (each attended one session; mean age, 43.4 years; 72.4% female). Mean time since confirmed diagnosis of MDD was 13.1 years. The most commonly prescribed antidepressants received were bupropion (41.4% of participants), escitalopram (34.5%), and sertraline (34.5%). The most frequently reported bothersome MDD symptoms were fatigue (mentioned by 58.6% of participants), lack of motivation/loss of interest (51.7%), anxiety/panic (44.8%), sadness (41.4%), and lack of concentration/brain fog (41.4%). Socialization, family life, and work were the areas in which quality of life was most impacted. Participants expressed dissatisfaction with their antidepressant treatment. Fast symptom resolution was mentioned as a priority (defined as <1 week by 38.5% of participants and ≤1 month by 65.4%). Most participants had not experienced fast relief from their symptoms with current or previous antidepressant medications. CONCLUSION: Results of this qualitative study suggest that fatigue, anhedonia, cognitive symptoms, and anxiety are some of the most bothersome symptoms for patients with MDD and highlight the importance of obtaining rapid relief from these symptoms in order to improve outcomes and patient satisfaction with antidepressant medication.
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spelling pubmed-84760862021-09-28 Patient Expectations and Experiences of Antidepressant Therapy for Major Depressive Disorder: A Qualitative Study Baune, Bernhard T Florea, Ioana Ebert, Bjarke Touya, Maëlys Ettrup, Anders Hadi, Monica Ren, Hongye Neuropsychiatr Dis Treat Original Research PURPOSE: This qualitative study explored patient perceptions of the most burdensome symptoms of major depressive disorder (MDD), the impact of symptoms on patients’ daily lives, and patient expectations and experiences regarding the timing of onset of antidepressant pharmacotherapy. PATIENTS AND METHODS: Data were collected through facilitated, patient focus-group sessions in the USA between May and June 2019. Participants were adults with confirmed MDD who reported a major depressive episode within the past 2 years, for which they had received pharmacologic treatment for ≥6 weeks. The semi-structured discussion focused on the key topics of bothersome symptoms of MDD, the impact of symptoms on quality of life, and the effects of antidepressant treatment. Interviews were audio-recorded; findings were summarized using a content-analysis approach. RESULTS: Five focus-group sessions were undertaken, involving a total of 29 patients (each attended one session; mean age, 43.4 years; 72.4% female). Mean time since confirmed diagnosis of MDD was 13.1 years. The most commonly prescribed antidepressants received were bupropion (41.4% of participants), escitalopram (34.5%), and sertraline (34.5%). The most frequently reported bothersome MDD symptoms were fatigue (mentioned by 58.6% of participants), lack of motivation/loss of interest (51.7%), anxiety/panic (44.8%), sadness (41.4%), and lack of concentration/brain fog (41.4%). Socialization, family life, and work were the areas in which quality of life was most impacted. Participants expressed dissatisfaction with their antidepressant treatment. Fast symptom resolution was mentioned as a priority (defined as <1 week by 38.5% of participants and ≤1 month by 65.4%). Most participants had not experienced fast relief from their symptoms with current or previous antidepressant medications. CONCLUSION: Results of this qualitative study suggest that fatigue, anhedonia, cognitive symptoms, and anxiety are some of the most bothersome symptoms for patients with MDD and highlight the importance of obtaining rapid relief from these symptoms in order to improve outcomes and patient satisfaction with antidepressant medication. Dove 2021-09-23 /pmc/articles/PMC8476086/ /pubmed/34588779 http://dx.doi.org/10.2147/NDT.S325954 Text en © 2021 Baune et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Baune, Bernhard T
Florea, Ioana
Ebert, Bjarke
Touya, Maëlys
Ettrup, Anders
Hadi, Monica
Ren, Hongye
Patient Expectations and Experiences of Antidepressant Therapy for Major Depressive Disorder: A Qualitative Study
title Patient Expectations and Experiences of Antidepressant Therapy for Major Depressive Disorder: A Qualitative Study
title_full Patient Expectations and Experiences of Antidepressant Therapy for Major Depressive Disorder: A Qualitative Study
title_fullStr Patient Expectations and Experiences of Antidepressant Therapy for Major Depressive Disorder: A Qualitative Study
title_full_unstemmed Patient Expectations and Experiences of Antidepressant Therapy for Major Depressive Disorder: A Qualitative Study
title_short Patient Expectations and Experiences of Antidepressant Therapy for Major Depressive Disorder: A Qualitative Study
title_sort patient expectations and experiences of antidepressant therapy for major depressive disorder: a qualitative study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476086/
https://www.ncbi.nlm.nih.gov/pubmed/34588779
http://dx.doi.org/10.2147/NDT.S325954
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