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Molecular Evolutionary Dynamics of Energy Limited Microorganisms
Microorganisms have the unique ability to survive extended periods of time in environments with extremely low levels of exploitable energy. To determine the extent that energy limitation affects microbial evolution, we examined the molecular evolutionary dynamics of a phylogenetically diverse set of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476154/ https://www.ncbi.nlm.nih.gov/pubmed/34255090 http://dx.doi.org/10.1093/molbev/msab195 |
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author | Shoemaker, William R Polezhaeva, Evgeniya Givens, Kenzie B Lennon, Jay T |
author_facet | Shoemaker, William R Polezhaeva, Evgeniya Givens, Kenzie B Lennon, Jay T |
author_sort | Shoemaker, William R |
collection | PubMed |
description | Microorganisms have the unique ability to survive extended periods of time in environments with extremely low levels of exploitable energy. To determine the extent that energy limitation affects microbial evolution, we examined the molecular evolutionary dynamics of a phylogenetically diverse set of taxa over the course of 1,000 days. We found that periodic exposure to energy limitation affected the rate of molecular evolution, the accumulation of genetic diversity, and the rate of extinction. We then determined the degree that energy limitation affected the spectrum of mutations as well as the direction of evolution at the gene level. Our results suggest that the initial depletion of energy altered the direction and rate of molecular evolution within each taxon, though after the initial depletion the rate and direction did not substantially change. However, this consistent pattern became diminished when comparisons were performed across phylogenetically distant taxa, suggesting that although the dynamics of molecular evolution under energy limitation are highly generalizable across the microbial tree of life, the targets of adaptation are specific to a given taxon. |
format | Online Article Text |
id | pubmed-8476154 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-84761542021-09-28 Molecular Evolutionary Dynamics of Energy Limited Microorganisms Shoemaker, William R Polezhaeva, Evgeniya Givens, Kenzie B Lennon, Jay T Mol Biol Evol Discoveries Microorganisms have the unique ability to survive extended periods of time in environments with extremely low levels of exploitable energy. To determine the extent that energy limitation affects microbial evolution, we examined the molecular evolutionary dynamics of a phylogenetically diverse set of taxa over the course of 1,000 days. We found that periodic exposure to energy limitation affected the rate of molecular evolution, the accumulation of genetic diversity, and the rate of extinction. We then determined the degree that energy limitation affected the spectrum of mutations as well as the direction of evolution at the gene level. Our results suggest that the initial depletion of energy altered the direction and rate of molecular evolution within each taxon, though after the initial depletion the rate and direction did not substantially change. However, this consistent pattern became diminished when comparisons were performed across phylogenetically distant taxa, suggesting that although the dynamics of molecular evolution under energy limitation are highly generalizable across the microbial tree of life, the targets of adaptation are specific to a given taxon. Oxford University Press 2021-07-13 /pmc/articles/PMC8476154/ /pubmed/34255090 http://dx.doi.org/10.1093/molbev/msab195 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Discoveries Shoemaker, William R Polezhaeva, Evgeniya Givens, Kenzie B Lennon, Jay T Molecular Evolutionary Dynamics of Energy Limited Microorganisms |
title | Molecular Evolutionary Dynamics of Energy Limited Microorganisms |
title_full | Molecular Evolutionary Dynamics of Energy Limited Microorganisms |
title_fullStr | Molecular Evolutionary Dynamics of Energy Limited Microorganisms |
title_full_unstemmed | Molecular Evolutionary Dynamics of Energy Limited Microorganisms |
title_short | Molecular Evolutionary Dynamics of Energy Limited Microorganisms |
title_sort | molecular evolutionary dynamics of energy limited microorganisms |
topic | Discoveries |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476154/ https://www.ncbi.nlm.nih.gov/pubmed/34255090 http://dx.doi.org/10.1093/molbev/msab195 |
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