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Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease

Appendiceal actinomycosis is very rare and its diagnosis is often difficult even in surgically resected specimens. Here we report two cases of appendiceal actinomycosis confirmed by pathologic examination of surgically resected specimens. Characteristic histologic features included transmural chroni...

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Autores principales: Sung, You-Na, Kim, Jihun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pathologists and the Korean Society for Cytopathology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476320/
https://www.ncbi.nlm.nih.gov/pubmed/32580538
http://dx.doi.org/10.4132/jptm.2020.05.17
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author Sung, You-Na
Kim, Jihun
author_facet Sung, You-Na
Kim, Jihun
author_sort Sung, You-Na
collection PubMed
description Appendiceal actinomycosis is very rare and its diagnosis is often difficult even in surgically resected specimens. Here we report two cases of appendiceal actinomycosis confirmed by pathologic examination of surgically resected specimens. Characteristic histologic features included transmural chronic inflammation with Crohn-like lymphoid aggregates and polypoid mucosal protrusion into cecal lumen through fibrous expansion of the submucosa. Chronic active inflammation involved the mucosa of the appendix and cecum around the appendiceal orifice. Crohn’s disease with predominant cecal involvement and inflammatory pseudotumor were considered as differential diagnoses. Careful examination revealed a few actinomycotic colonies in the mucosa, confirming the diagnosis. A high index of suspicion with awareness of the characteristic histologic features might prompt careful inspection for the actinomycotic colonies, leading to the appropriate diagnosis of this rare disease.
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spelling pubmed-84763202021-10-07 Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease Sung, You-Na Kim, Jihun J Pathol Transl Med Case Study Appendiceal actinomycosis is very rare and its diagnosis is often difficult even in surgically resected specimens. Here we report two cases of appendiceal actinomycosis confirmed by pathologic examination of surgically resected specimens. Characteristic histologic features included transmural chronic inflammation with Crohn-like lymphoid aggregates and polypoid mucosal protrusion into cecal lumen through fibrous expansion of the submucosa. Chronic active inflammation involved the mucosa of the appendix and cecum around the appendiceal orifice. Crohn’s disease with predominant cecal involvement and inflammatory pseudotumor were considered as differential diagnoses. Careful examination revealed a few actinomycotic colonies in the mucosa, confirming the diagnosis. A high index of suspicion with awareness of the characteristic histologic features might prompt careful inspection for the actinomycotic colonies, leading to the appropriate diagnosis of this rare disease. The Korean Society of Pathologists and the Korean Society for Cytopathology 2021-09 2020-06-26 /pmc/articles/PMC8476320/ /pubmed/32580538 http://dx.doi.org/10.4132/jptm.2020.05.17 Text en © 2021 The Korean Society of Pathologists/The Korean Society for Cytopathology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Study
Sung, You-Na
Kim, Jihun
Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease
title Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease
title_full Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease
title_fullStr Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease
title_full_unstemmed Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease
title_short Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease
title_sort appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476320/
https://www.ncbi.nlm.nih.gov/pubmed/32580538
http://dx.doi.org/10.4132/jptm.2020.05.17
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