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Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease
Appendiceal actinomycosis is very rare and its diagnosis is often difficult even in surgically resected specimens. Here we report two cases of appendiceal actinomycosis confirmed by pathologic examination of surgically resected specimens. Characteristic histologic features included transmural chroni...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Pathologists and the Korean Society for Cytopathology
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476320/ https://www.ncbi.nlm.nih.gov/pubmed/32580538 http://dx.doi.org/10.4132/jptm.2020.05.17 |
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author | Sung, You-Na Kim, Jihun |
author_facet | Sung, You-Na Kim, Jihun |
author_sort | Sung, You-Na |
collection | PubMed |
description | Appendiceal actinomycosis is very rare and its diagnosis is often difficult even in surgically resected specimens. Here we report two cases of appendiceal actinomycosis confirmed by pathologic examination of surgically resected specimens. Characteristic histologic features included transmural chronic inflammation with Crohn-like lymphoid aggregates and polypoid mucosal protrusion into cecal lumen through fibrous expansion of the submucosa. Chronic active inflammation involved the mucosa of the appendix and cecum around the appendiceal orifice. Crohn’s disease with predominant cecal involvement and inflammatory pseudotumor were considered as differential diagnoses. Careful examination revealed a few actinomycotic colonies in the mucosa, confirming the diagnosis. A high index of suspicion with awareness of the characteristic histologic features might prompt careful inspection for the actinomycotic colonies, leading to the appropriate diagnosis of this rare disease. |
format | Online Article Text |
id | pubmed-8476320 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Korean Society of Pathologists and the Korean Society for Cytopathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-84763202021-10-07 Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease Sung, You-Na Kim, Jihun J Pathol Transl Med Case Study Appendiceal actinomycosis is very rare and its diagnosis is often difficult even in surgically resected specimens. Here we report two cases of appendiceal actinomycosis confirmed by pathologic examination of surgically resected specimens. Characteristic histologic features included transmural chronic inflammation with Crohn-like lymphoid aggregates and polypoid mucosal protrusion into cecal lumen through fibrous expansion of the submucosa. Chronic active inflammation involved the mucosa of the appendix and cecum around the appendiceal orifice. Crohn’s disease with predominant cecal involvement and inflammatory pseudotumor were considered as differential diagnoses. Careful examination revealed a few actinomycotic colonies in the mucosa, confirming the diagnosis. A high index of suspicion with awareness of the characteristic histologic features might prompt careful inspection for the actinomycotic colonies, leading to the appropriate diagnosis of this rare disease. The Korean Society of Pathologists and the Korean Society for Cytopathology 2021-09 2020-06-26 /pmc/articles/PMC8476320/ /pubmed/32580538 http://dx.doi.org/10.4132/jptm.2020.05.17 Text en © 2021 The Korean Society of Pathologists/The Korean Society for Cytopathology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Study Sung, You-Na Kim, Jihun Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease |
title | Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease |
title_full | Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease |
title_fullStr | Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease |
title_full_unstemmed | Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease |
title_short | Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease |
title_sort | appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease |
topic | Case Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476320/ https://www.ncbi.nlm.nih.gov/pubmed/32580538 http://dx.doi.org/10.4132/jptm.2020.05.17 |
work_keys_str_mv | AT sungyouna appendicealactinomycosismimickingappendicealtumorappendicitisorinflammatoryboweldisease AT kimjihun appendicealactinomycosismimickingappendicealtumorappendicitisorinflammatoryboweldisease |