Teriflunomide – The common drug with underestimated oxygen - Dependent anticancer potential

Leflunomide (LFN) is a well-known immunomodulatory and anti-inflammatory prodrug of teriflunomide (TFN). Due to pyrimidine synthesis inhibition TFN also exhibits potent anticancer effect. Because, there is the strict coupling between the pyrimidine synthesis and the mitochondrial respiratory chain,...

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Detalles Bibliográficos
Autores principales: Otto-Ślusarczyk, Dagmara, Graboń, Wojciech, Mielczarek-Puta, Magdalena, Chrzanowska, Alicja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476349/
https://www.ncbi.nlm.nih.gov/pubmed/34611552
http://dx.doi.org/10.1016/j.bbrep.2021.101141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476349/
https://www.ncbi.nlm.nih.gov/pubmed/34611552
http://dx.doi.org/10.1016/j.bbrep.2021.101141

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