Direct tissue-sensing reprograms TLR4(+) Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients

CD4(+) T cells mediate rheumatoid arthritis (RA) pathogenesis through both antibody-dependent and independent mechanisms. It remains unclear how synovial microenvironment impinges on CD4(+) T cells pathogenic functions. Here, we identified a TLR4(+) follicular helper T (Tfh) cell-like population pre...

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Detalles Bibliográficos
Autores principales: Amaral-Silva, Daniela, Gonçalves, Rute, Torrão, Rita C., Torres, Rita, Falcão, Sandra, Gonçalves, Maria João, Araújo, Maria Paula, Martins, Maria José, Lopes, Carina, Neto, Agna, Marona, José, Costa, Tiago, Castelão, Walter, Silva, Ana Bento, Silva, Inês, Lourenço, Maria Helena, Mateus, Margarida, Gonçalves, Nuno Pina, Manica, Santiago, Costa, Manuela, Pimentel-Santos, Fernando M., Mourão, Ana Filipa, Branco, Jaime C., Soares, Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476501/
https://www.ncbi.nlm.nih.gov/pubmed/34580414
http://dx.doi.org/10.1038/s42003-021-02659-0

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