Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

There is an urgent need for animal models to study SARS-CoV-2 pathogenicity. Here, we generate and characterize a novel mouse-adapted SARS-CoV-2 strain, MASCp36, that causes severe respiratory symptoms, and mortality. Our model exhibits age- and gender-related mortality akin to severe COVID-19. Deep...

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Detalles Bibliográficos
Autores principales: Sun, Shihui, Gu, Hongjing, Cao, Lei, Chen, Qi, Ye, Qing, Yang, Guan, Li, Rui-Ting, Fan, Hang, Deng, Yong-Qiang, Song, Xiaopeng, Qi, Yini, Li, Min, Lan, Jun, Feng, Rui, Guo, Yan, Zhu, Na, Qin, Si, Wang, Lei, Zhang, Yi-Fei, Zhou, Chao, Zhao, Lingna, Chen, Yuehong, Shen, Meng, Cui, Yujun, Yang, Xiao, Wang, Xinquan, Tan, Wenjie, Wang, Hui, Wang, Xiangxi, Qin, Cheng-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476561/
https://www.ncbi.nlm.nih.gov/pubmed/34580297
http://dx.doi.org/10.1038/s41467-021-25903-x

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