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Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer

Only a subgroup of triple-negative breast cancer (TNBC) responds to immune checkpoint inhibitors (ICI). To better understand lack of response to ICI, we analyze 681 TNBCs for spatial immune cell contextures in relation to clinical outcomes and pathways of T cell evasion. Excluded, ignored and inflam...

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Detalles Bibliográficos
Autores principales:	Hammerl, Dora, Martens, John W. M., Timmermans, Mieke, Smid, Marcel, Trapman-Jansen, Anita M., Foekens, Renée, Isaeva, Olga I., Voorwerk, Leonie, Balcioglu, Hayri E., Wijers, Rebecca, Nederlof, Iris, Salgado, Roberto, Horlings, Hugo, Kok, Marleen, Debets, Reno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476574/ https://www.ncbi.nlm.nih.gov/pubmed/34580291 http://dx.doi.org/10.1038/s41467-021-25962-0

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