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Racial and ethnic differences in severity of coronary calcification among patients undergoing PCI: Results from a single-center multiethnic PCI registry

BACKGROUND: Although population-based studies have demonstrated racial heterogeneity in coronary artery calcium (CAC) burden, the degree to which such associations extend to percutaneous coronary intervention (PCI) cohorts remains poorly characterized. We sought to evaluate the associations between...

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Autores principales: Bienstock, Solomon W., Samtani, Rajeev, Lai, Ashton C., Baber, Usman, Sperling, Dylan, Camaj, Anton, Feinman, Jason, Ting, Peter, Kocovic, Nikola, Li, Emily, Goldman, Martin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476687/
https://www.ncbi.nlm.nih.gov/pubmed/34611544
http://dx.doi.org/10.1016/j.ijcha.2021.100877
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author Bienstock, Solomon W.
Samtani, Rajeev
Lai, Ashton C.
Baber, Usman
Sperling, Dylan
Camaj, Anton
Feinman, Jason
Ting, Peter
Kocovic, Nikola
Li, Emily
Goldman, Martin E.
author_facet Bienstock, Solomon W.
Samtani, Rajeev
Lai, Ashton C.
Baber, Usman
Sperling, Dylan
Camaj, Anton
Feinman, Jason
Ting, Peter
Kocovic, Nikola
Li, Emily
Goldman, Martin E.
author_sort Bienstock, Solomon W.
collection PubMed
description BACKGROUND: Although population-based studies have demonstrated racial heterogeneity in coronary artery calcium (CAC) burden, the degree to which such associations extend to percutaneous coronary intervention (PCI) cohorts remains poorly characterized. We sought to evaluate the associations between race/ethnicity and CAC in a PCI population. METHODS: This single center retrospective study analyzed 1025 patients with prior CAC who underwent PCI between January 1, 2012 and May 15, 2020. Patients were grouped as non-Hispanic White (NHW, N = 779), non-Hispanic Black (NHB, N = 81) and Hispanic (H, N = 165). Associations between race and CAC (Agatston units) were examined using negative binomial regression while adjusting for baseline parameters. RESULTS: Among the 1025 patients (mean age 65.8, 70% male) who underwent PCI, NHW, NHB, and H populations had median CAC scores of 760, 500, and 462 Agatston units, respectively (p < 0.0001). Hispanic patients displayed a higher burden of diabetes mellitus, hypertension and hyperlipidemia compared with other groups. After adjusting for baseline differences and compared with NHW, the inverse association between Hispanic and CAC persisted (β = -324.1, p < 0.0001) whereas differences were not significant for NHB (β = -51.5, p = 0.67). CONCLUSIONS: Despite a higher risk clinical phenotype, Hispanic patients who underwent PCI had significantly lower CAC compared with non-Hispanic patients. Thus, current risk stratification models using universalized CAC scores may underestimate the risk for the Hispanic population. Race/ethnicity-informed CAC thresholds may better guide clinical decisions.
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spelling pubmed-84766872021-10-04 Racial and ethnic differences in severity of coronary calcification among patients undergoing PCI: Results from a single-center multiethnic PCI registry Bienstock, Solomon W. Samtani, Rajeev Lai, Ashton C. Baber, Usman Sperling, Dylan Camaj, Anton Feinman, Jason Ting, Peter Kocovic, Nikola Li, Emily Goldman, Martin E. Int J Cardiol Heart Vasc Original Paper BACKGROUND: Although population-based studies have demonstrated racial heterogeneity in coronary artery calcium (CAC) burden, the degree to which such associations extend to percutaneous coronary intervention (PCI) cohorts remains poorly characterized. We sought to evaluate the associations between race/ethnicity and CAC in a PCI population. METHODS: This single center retrospective study analyzed 1025 patients with prior CAC who underwent PCI between January 1, 2012 and May 15, 2020. Patients were grouped as non-Hispanic White (NHW, N = 779), non-Hispanic Black (NHB, N = 81) and Hispanic (H, N = 165). Associations between race and CAC (Agatston units) were examined using negative binomial regression while adjusting for baseline parameters. RESULTS: Among the 1025 patients (mean age 65.8, 70% male) who underwent PCI, NHW, NHB, and H populations had median CAC scores of 760, 500, and 462 Agatston units, respectively (p < 0.0001). Hispanic patients displayed a higher burden of diabetes mellitus, hypertension and hyperlipidemia compared with other groups. After adjusting for baseline differences and compared with NHW, the inverse association between Hispanic and CAC persisted (β = -324.1, p < 0.0001) whereas differences were not significant for NHB (β = -51.5, p = 0.67). CONCLUSIONS: Despite a higher risk clinical phenotype, Hispanic patients who underwent PCI had significantly lower CAC compared with non-Hispanic patients. Thus, current risk stratification models using universalized CAC scores may underestimate the risk for the Hispanic population. Race/ethnicity-informed CAC thresholds may better guide clinical decisions. Elsevier 2021-09-24 /pmc/articles/PMC8476687/ /pubmed/34611544 http://dx.doi.org/10.1016/j.ijcha.2021.100877 Text en © 2021 The Authors. Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Paper
Bienstock, Solomon W.
Samtani, Rajeev
Lai, Ashton C.
Baber, Usman
Sperling, Dylan
Camaj, Anton
Feinman, Jason
Ting, Peter
Kocovic, Nikola
Li, Emily
Goldman, Martin E.
Racial and ethnic differences in severity of coronary calcification among patients undergoing PCI: Results from a single-center multiethnic PCI registry
title Racial and ethnic differences in severity of coronary calcification among patients undergoing PCI: Results from a single-center multiethnic PCI registry
title_full Racial and ethnic differences in severity of coronary calcification among patients undergoing PCI: Results from a single-center multiethnic PCI registry
title_fullStr Racial and ethnic differences in severity of coronary calcification among patients undergoing PCI: Results from a single-center multiethnic PCI registry
title_full_unstemmed Racial and ethnic differences in severity of coronary calcification among patients undergoing PCI: Results from a single-center multiethnic PCI registry
title_short Racial and ethnic differences in severity of coronary calcification among patients undergoing PCI: Results from a single-center multiethnic PCI registry
title_sort racial and ethnic differences in severity of coronary calcification among patients undergoing pci: results from a single-center multiethnic pci registry
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476687/
https://www.ncbi.nlm.nih.gov/pubmed/34611544
http://dx.doi.org/10.1016/j.ijcha.2021.100877
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