Molecular Determinants and Pharmacological Analysis for a Class of Competitive Non-transported Bicyclic Inhibitors of the Betaine/GABA Transporter BGT1

The betaine/GABA transporter 1 (BGT1) is a member of the GABA transporter (GAT) family with still elusive function, largely due to a lack of potent and selective tool compounds. Based on modeling, we here present the design, synthesis and pharmacological evaluation of five novel conformationally res...

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Detalles Bibliográficos
Autores principales: Kickinger, Stefanie, Lie, Maria E. K., Suemasa, Akihiro, Al-Khawaja, Anas, Fujiwara, Koichi, Watanabe, Mizuki, Wilhelmsen, Kristine S., Falk-Petersen, Christina B., Frølund, Bente, Shuto, Satoshi, Ecker, Gerhard F., Wellendorph, Petrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476755/
https://www.ncbi.nlm.nih.gov/pubmed/34595152
http://dx.doi.org/10.3389/fchem.2021.736457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476755/
https://www.ncbi.nlm.nih.gov/pubmed/34595152
http://dx.doi.org/10.3389/fchem.2021.736457

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