An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation

OBJECTIVE: The loss of forkhead box protein O1 (FoxO1) signaling in response to metabolic stress contributes to the etiology of type II diabetes, causing the dedifferentiation of pancreatic beta cells to a cell type reminiscent of endocrine progenitors. Lack of methods to easily model this process i...

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Detalles Bibliográficos
Autores principales: Casteels, Tamara, Zhang, Yufeng, Frogne, Thomas, Sturtzel, Caterina, Lardeau, Charles-Hugues, Sen, Ilke, Liu, Xiaocheng, Hong, Shangyu, Pauler, Florian M., Penz, Thomas, Brandstetter, Marlene, Barbieux, Charlotte, Berishvili, Ekaterine, Heuser, Thomas, Bock, Christoph, Riedel, Christian G., Meyer, Dirk, Distel, Martin, Hecksher-Sørensen, Jacob, Li, Jin, Kubicek, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476777/
https://www.ncbi.nlm.nih.gov/pubmed/34454092
http://dx.doi.org/10.1016/j.molmet.2021.101329

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