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Role of Interleukin-17 in Acute Pancreatitis
Acute pancreatitis (AP) is a leading cause of death and is commonly accompanied by systemic manifestations that are generally associated with a poor prognosis. Many cytokines contribute to pancreatic tissue damage and cause systemic injury. Interleukin-17 (IL-17) is a cytokine that may play a vital...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476864/ https://www.ncbi.nlm.nih.gov/pubmed/34594321 http://dx.doi.org/10.3389/fimmu.2021.674803 |
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author | Li, Guanqun Chen, Hongze Liu, Liwei Xiao, Peng Xie, Yu Geng, Xinglong Zhang, Tao Zhang, Yang Lu, Tianqi Tan, Hongtao Li, Le Sun, Bei |
author_facet | Li, Guanqun Chen, Hongze Liu, Liwei Xiao, Peng Xie, Yu Geng, Xinglong Zhang, Tao Zhang, Yang Lu, Tianqi Tan, Hongtao Li, Le Sun, Bei |
author_sort | Li, Guanqun |
collection | PubMed |
description | Acute pancreatitis (AP) is a leading cause of death and is commonly accompanied by systemic manifestations that are generally associated with a poor prognosis. Many cytokines contribute to pancreatic tissue damage and cause systemic injury. Interleukin-17 (IL-17) is a cytokine that may play a vital role in AP. Specifically, IL-17 has important effects on the immune response and causes interactions between different inflammatory mediators in the AP-related microenvironment. In this literature review, we will discuss the existing academic understanding of IL-17 and the impacts of IL-17 in different cells (especially in acinar cells and immune system cells) in AP pathogenesis. The clinical significance and potential mechanisms of IL-17 on AP deterioration are emphasized. The evidence suggests that inhibiting the IL-17 cytokine family could alleviate the pathogenic process of AP, and we highlight therapeutic strategies that directly or indirectly target IL-17 cytokines in acute pancreatitis. |
format | Online Article Text |
id | pubmed-8476864 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84768642021-09-29 Role of Interleukin-17 in Acute Pancreatitis Li, Guanqun Chen, Hongze Liu, Liwei Xiao, Peng Xie, Yu Geng, Xinglong Zhang, Tao Zhang, Yang Lu, Tianqi Tan, Hongtao Li, Le Sun, Bei Front Immunol Immunology Acute pancreatitis (AP) is a leading cause of death and is commonly accompanied by systemic manifestations that are generally associated with a poor prognosis. Many cytokines contribute to pancreatic tissue damage and cause systemic injury. Interleukin-17 (IL-17) is a cytokine that may play a vital role in AP. Specifically, IL-17 has important effects on the immune response and causes interactions between different inflammatory mediators in the AP-related microenvironment. In this literature review, we will discuss the existing academic understanding of IL-17 and the impacts of IL-17 in different cells (especially in acinar cells and immune system cells) in AP pathogenesis. The clinical significance and potential mechanisms of IL-17 on AP deterioration are emphasized. The evidence suggests that inhibiting the IL-17 cytokine family could alleviate the pathogenic process of AP, and we highlight therapeutic strategies that directly or indirectly target IL-17 cytokines in acute pancreatitis. Frontiers Media S.A. 2021-09-14 /pmc/articles/PMC8476864/ /pubmed/34594321 http://dx.doi.org/10.3389/fimmu.2021.674803 Text en Copyright © 2021 Li, Chen, Liu, Xiao, Xie, Geng, Zhang, Zhang, Lu, Tan, Li and Sun https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Li, Guanqun Chen, Hongze Liu, Liwei Xiao, Peng Xie, Yu Geng, Xinglong Zhang, Tao Zhang, Yang Lu, Tianqi Tan, Hongtao Li, Le Sun, Bei Role of Interleukin-17 in Acute Pancreatitis |
title | Role of Interleukin-17 in Acute Pancreatitis |
title_full | Role of Interleukin-17 in Acute Pancreatitis |
title_fullStr | Role of Interleukin-17 in Acute Pancreatitis |
title_full_unstemmed | Role of Interleukin-17 in Acute Pancreatitis |
title_short | Role of Interleukin-17 in Acute Pancreatitis |
title_sort | role of interleukin-17 in acute pancreatitis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476864/ https://www.ncbi.nlm.nih.gov/pubmed/34594321 http://dx.doi.org/10.3389/fimmu.2021.674803 |
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