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Role of AMH in Prediction of Menopause

Anti-Müllerian Hormone (AMH) is produced by small antral follicles and has evolved over the past three decades as an assumed potential marker of the number of follicles in the human ovaries, also known as ovarian reserve. This quantitative measure, given the gradual decline over time and its non-rep...

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Autores principales: de Kat, Annelien C., Broekmans, Frank J. M., Lambalk, Cornelis B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476919/
https://www.ncbi.nlm.nih.gov/pubmed/34594304
http://dx.doi.org/10.3389/fendo.2021.733731
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author de Kat, Annelien C.
Broekmans, Frank J. M.
Lambalk, Cornelis B.
author_facet de Kat, Annelien C.
Broekmans, Frank J. M.
Lambalk, Cornelis B.
author_sort de Kat, Annelien C.
collection PubMed
description Anti-Müllerian Hormone (AMH) is produced by small antral follicles and has evolved over the past three decades as an assumed potential marker of the number of follicles in the human ovaries, also known as ovarian reserve. This quantitative measure, given the gradual decline over time and its non-replenishable feature, could be the dreamed marker for predicting the final exhaustion of ovarian storage: the post-menopause. This introductory chapter summarizes current knowledge with regard to the contribution of serum AMH measurements to predict age of normal menopause and critically discuss its potential in this regard. Furthermore, its predictive role in the context of menopause in association with several frequently occurring fertility disorders such as premature menopause, polycystic ovarian syndrome and endometriosis are discussed. Overall, while ovarian reserve markers including AMH are unmistakably related to age at menopause, they are insufficiently precise to inform on an individual’s journey of ovarian aging.
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spelling pubmed-84769192021-09-29 Role of AMH in Prediction of Menopause de Kat, Annelien C. Broekmans, Frank J. M. Lambalk, Cornelis B. Front Endocrinol (Lausanne) Endocrinology Anti-Müllerian Hormone (AMH) is produced by small antral follicles and has evolved over the past three decades as an assumed potential marker of the number of follicles in the human ovaries, also known as ovarian reserve. This quantitative measure, given the gradual decline over time and its non-replenishable feature, could be the dreamed marker for predicting the final exhaustion of ovarian storage: the post-menopause. This introductory chapter summarizes current knowledge with regard to the contribution of serum AMH measurements to predict age of normal menopause and critically discuss its potential in this regard. Furthermore, its predictive role in the context of menopause in association with several frequently occurring fertility disorders such as premature menopause, polycystic ovarian syndrome and endometriosis are discussed. Overall, while ovarian reserve markers including AMH are unmistakably related to age at menopause, they are insufficiently precise to inform on an individual’s journey of ovarian aging. Frontiers Media S.A. 2021-09-14 /pmc/articles/PMC8476919/ /pubmed/34594304 http://dx.doi.org/10.3389/fendo.2021.733731 Text en Copyright © 2021 de Kat, Broekmans and Lambalk https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
de Kat, Annelien C.
Broekmans, Frank J. M.
Lambalk, Cornelis B.
Role of AMH in Prediction of Menopause
title Role of AMH in Prediction of Menopause
title_full Role of AMH in Prediction of Menopause
title_fullStr Role of AMH in Prediction of Menopause
title_full_unstemmed Role of AMH in Prediction of Menopause
title_short Role of AMH in Prediction of Menopause
title_sort role of amh in prediction of menopause
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476919/
https://www.ncbi.nlm.nih.gov/pubmed/34594304
http://dx.doi.org/10.3389/fendo.2021.733731
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