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Case Report: A Rare Case of Coexisting of Autoimmune Polyglandular Syndrome Type 3 and Isolated Gonadotropin-Releasing Hormone Deficiency

APS (autoimmune polyglandular syndrome) is defined as the coexistence of at least two kinds of endocrine autoimmune diseases. APS type 3 comprises autoimmune thyroid diseases and other autoimmune diseases but does not involve autoimmune Addison’s disease. So far, APS-3 combined with isolated gonadot...

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Autores principales: Jiang, Qiuhui, Wu, Ting, Zhang, Yuxian, Wang, Shunhua, Wang, Liying, Su, Weijuan, Lin, Mingzhu, Li, Xuejun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476964/
https://www.ncbi.nlm.nih.gov/pubmed/34594339
http://dx.doi.org/10.3389/fimmu.2021.734685
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author Jiang, Qiuhui
Wu, Ting
Zhang, Yuxian
Wang, Shunhua
Wang, Liying
Su, Weijuan
Lin, Mingzhu
Li, Xuejun
author_facet Jiang, Qiuhui
Wu, Ting
Zhang, Yuxian
Wang, Shunhua
Wang, Liying
Su, Weijuan
Lin, Mingzhu
Li, Xuejun
author_sort Jiang, Qiuhui
collection PubMed
description APS (autoimmune polyglandular syndrome) is defined as the coexistence of at least two kinds of endocrine autoimmune diseases. APS type 3 comprises autoimmune thyroid diseases and other autoimmune diseases but does not involve autoimmune Addison’s disease. So far, APS-3 combined with isolated gonadotropin-releasing hormone (GnRH) reduction caused by the suspected autoimmune hypothalamic disease has not been reported. We recently received a 43-year-old woman with a one-year history of Graves’ disease (GD) and a four-month history of type 1 diabetes presented with hyperthyroidism and hyperglycemia. After the GnRH stimulation test, she was diagnosed with secondary amenorrhea attributed to suspected autoimmune Hypothalamitis and APS type 3 associated with Graves’ disease and Latent Autoimmune Diabetes (LADA). According to this case, the hypothalamus cannot be spared from the general autoimmune process. It is recommended to carry out the GnRH stimulation test when encountering APS patients combined with secondary amenorrhea.
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spelling pubmed-84769642021-09-29 Case Report: A Rare Case of Coexisting of Autoimmune Polyglandular Syndrome Type 3 and Isolated Gonadotropin-Releasing Hormone Deficiency Jiang, Qiuhui Wu, Ting Zhang, Yuxian Wang, Shunhua Wang, Liying Su, Weijuan Lin, Mingzhu Li, Xuejun Front Immunol Immunology APS (autoimmune polyglandular syndrome) is defined as the coexistence of at least two kinds of endocrine autoimmune diseases. APS type 3 comprises autoimmune thyroid diseases and other autoimmune diseases but does not involve autoimmune Addison’s disease. So far, APS-3 combined with isolated gonadotropin-releasing hormone (GnRH) reduction caused by the suspected autoimmune hypothalamic disease has not been reported. We recently received a 43-year-old woman with a one-year history of Graves’ disease (GD) and a four-month history of type 1 diabetes presented with hyperthyroidism and hyperglycemia. After the GnRH stimulation test, she was diagnosed with secondary amenorrhea attributed to suspected autoimmune Hypothalamitis and APS type 3 associated with Graves’ disease and Latent Autoimmune Diabetes (LADA). According to this case, the hypothalamus cannot be spared from the general autoimmune process. It is recommended to carry out the GnRH stimulation test when encountering APS patients combined with secondary amenorrhea. Frontiers Media S.A. 2021-09-14 /pmc/articles/PMC8476964/ /pubmed/34594339 http://dx.doi.org/10.3389/fimmu.2021.734685 Text en Copyright © 2021 Jiang, Wu, Zhang, Wang, Wang, Su, Lin and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Jiang, Qiuhui
Wu, Ting
Zhang, Yuxian
Wang, Shunhua
Wang, Liying
Su, Weijuan
Lin, Mingzhu
Li, Xuejun
Case Report: A Rare Case of Coexisting of Autoimmune Polyglandular Syndrome Type 3 and Isolated Gonadotropin-Releasing Hormone Deficiency
title Case Report: A Rare Case of Coexisting of Autoimmune Polyglandular Syndrome Type 3 and Isolated Gonadotropin-Releasing Hormone Deficiency
title_full Case Report: A Rare Case of Coexisting of Autoimmune Polyglandular Syndrome Type 3 and Isolated Gonadotropin-Releasing Hormone Deficiency
title_fullStr Case Report: A Rare Case of Coexisting of Autoimmune Polyglandular Syndrome Type 3 and Isolated Gonadotropin-Releasing Hormone Deficiency
title_full_unstemmed Case Report: A Rare Case of Coexisting of Autoimmune Polyglandular Syndrome Type 3 and Isolated Gonadotropin-Releasing Hormone Deficiency
title_short Case Report: A Rare Case of Coexisting of Autoimmune Polyglandular Syndrome Type 3 and Isolated Gonadotropin-Releasing Hormone Deficiency
title_sort case report: a rare case of coexisting of autoimmune polyglandular syndrome type 3 and isolated gonadotropin-releasing hormone deficiency
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476964/
https://www.ncbi.nlm.nih.gov/pubmed/34594339
http://dx.doi.org/10.3389/fimmu.2021.734685
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