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Metabolic syndrome and breast cancer: a dangerous association for postmenopausal women. A postmenopausal women prevention study
BACKGROUND: Breast cancer(BC) is the most common cancer in women worldwide, the relationship between metabolic syndrome(MetS) and BC needs to be better clarified. Today the early diagnosis of breast cancer(BC) is yet a challenging problem in clinical practice, so the evidence that a well identified...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mattioli 1885
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477089/ https://www.ncbi.nlm.nih.gov/pubmed/34487081 http://dx.doi.org/10.23750/abm.v92i4.11335 |
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author | Maiello, Maria Cecere, Annagrazia Ciccone, Marco Matteo Palmiero, Pasquale |
author_facet | Maiello, Maria Cecere, Annagrazia Ciccone, Marco Matteo Palmiero, Pasquale |
author_sort | Maiello, Maria |
collection | PubMed |
description | BACKGROUND: Breast cancer(BC) is the most common cancer in women worldwide, the relationship between metabolic syndrome(MetS) and BC needs to be better clarified. Today the early diagnosis of breast cancer(BC) is yet a challenging problem in clinical practice, so the evidence that a well identified population of postmenopausal women, affected by MetS, presents a high risk, of breast cancer occurrence, is useful for breast cancer prevention. Our study aims to assess the prevalence of metabolic syndrome, diagnosed according to current guidelines, in postmenopausal women with breast cancer, and its role as an independent risk factor. RESULTS: MetS rate was significantly higher among women affected by BC:10.1%, 33 women, than CG:5.4%, 18 women, Chi-squared4.8,Odds ratio1.94,c.i.95%,p<0.02. Metabolic cardiomyopathy rate was significantly higher among women affected by BC:5.8%, 18 women, than CG:1.8%, 6 women, Chi-squared6.5,Odds ratio3.2,c.i.95%,p<0.01. Otherwise MetS rate without cardiomyopathy was higher among women affected by BC:4.8%, 15 women, than CG:3.4%, 11 women, but in a not statistically significant way, Chi-squared0.8,Odds ratio1.35,c.i.95%,p<0.36. CONCLUSION: There was a significant relationship, in our population, between MetS and BC, adding evidence to this controversial association, the relationship was even tighter, when restricted to women affected by metabolic cardiomyopathy; otherwise it, restricted to women affected by MetS, without metabolic cardiomyopathy, was not statistically significant. Since the prevalence of MetS is increasing worldwide, just like the incidence of BC, an intervention is needed to improve physical activity and weight reduction to decrease the MetS rate. |
format | Online Article Text |
id | pubmed-8477089 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Mattioli 1885 |
record_format | MEDLINE/PubMed |
spelling | pubmed-84770892021-10-08 Metabolic syndrome and breast cancer: a dangerous association for postmenopausal women. A postmenopausal women prevention study Maiello, Maria Cecere, Annagrazia Ciccone, Marco Matteo Palmiero, Pasquale Acta Biomed Original Article BACKGROUND: Breast cancer(BC) is the most common cancer in women worldwide, the relationship between metabolic syndrome(MetS) and BC needs to be better clarified. Today the early diagnosis of breast cancer(BC) is yet a challenging problem in clinical practice, so the evidence that a well identified population of postmenopausal women, affected by MetS, presents a high risk, of breast cancer occurrence, is useful for breast cancer prevention. Our study aims to assess the prevalence of metabolic syndrome, diagnosed according to current guidelines, in postmenopausal women with breast cancer, and its role as an independent risk factor. RESULTS: MetS rate was significantly higher among women affected by BC:10.1%, 33 women, than CG:5.4%, 18 women, Chi-squared4.8,Odds ratio1.94,c.i.95%,p<0.02. Metabolic cardiomyopathy rate was significantly higher among women affected by BC:5.8%, 18 women, than CG:1.8%, 6 women, Chi-squared6.5,Odds ratio3.2,c.i.95%,p<0.01. Otherwise MetS rate without cardiomyopathy was higher among women affected by BC:4.8%, 15 women, than CG:3.4%, 11 women, but in a not statistically significant way, Chi-squared0.8,Odds ratio1.35,c.i.95%,p<0.36. CONCLUSION: There was a significant relationship, in our population, between MetS and BC, adding evidence to this controversial association, the relationship was even tighter, when restricted to women affected by metabolic cardiomyopathy; otherwise it, restricted to women affected by MetS, without metabolic cardiomyopathy, was not statistically significant. Since the prevalence of MetS is increasing worldwide, just like the incidence of BC, an intervention is needed to improve physical activity and weight reduction to decrease the MetS rate. Mattioli 1885 2021 2021-09-02 /pmc/articles/PMC8477089/ /pubmed/34487081 http://dx.doi.org/10.23750/abm.v92i4.11335 Text en Copyright: © 2021 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License |
spellingShingle | Original Article Maiello, Maria Cecere, Annagrazia Ciccone, Marco Matteo Palmiero, Pasquale Metabolic syndrome and breast cancer: a dangerous association for postmenopausal women. A postmenopausal women prevention study |
title | Metabolic syndrome and breast cancer: a dangerous association for postmenopausal women. A postmenopausal women prevention study |
title_full | Metabolic syndrome and breast cancer: a dangerous association for postmenopausal women. A postmenopausal women prevention study |
title_fullStr | Metabolic syndrome and breast cancer: a dangerous association for postmenopausal women. A postmenopausal women prevention study |
title_full_unstemmed | Metabolic syndrome and breast cancer: a dangerous association for postmenopausal women. A postmenopausal women prevention study |
title_short | Metabolic syndrome and breast cancer: a dangerous association for postmenopausal women. A postmenopausal women prevention study |
title_sort | metabolic syndrome and breast cancer: a dangerous association for postmenopausal women. a postmenopausal women prevention study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477089/ https://www.ncbi.nlm.nih.gov/pubmed/34487081 http://dx.doi.org/10.23750/abm.v92i4.11335 |
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