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Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β

In Alzheimer's disease (AD), deposition of pathological tau and amyloid-β (Aβ) drive synaptic loss and cognitive decline. The injection of misfolded tau aggregates extracted from human AD brains drives templated spreading of tau pathology within WT mouse brain. Here, we assessed the impact of A...

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Detalles Bibliográficos
Autores principales:	Nies, Sarah Helena, Takahashi, Hideyuki, Herber, Charlotte S., Huttner, Anita, Chase, Alison, Strittmatter, Stephen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477193/ https://www.ncbi.nlm.nih.gov/pubmed/34480901 http://dx.doi.org/10.1016/j.jbc.2021.101159

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