Age-dependent upregulation of Y RNAs in Caenorhabditis elegans

Y RNA is a conserved small non-coding RNA whose functions in aging remain unknown. Here, we sought to determine the role of C. elegans Y RNA homologs, CeY RNA (CeY) and stem-bulge RNAs (sbRNAs), in aging. We found that the levels of CeY and sbRNAs generally increased during aging. We showed that CeY...

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Detalles Bibliográficos
Autores principales: Park, Sangsoon, Sohn, Jooyeon, Kwon, Sujeong, Kim, Eun Ji E, Jung, Yoonji, Park, Hae-Eun H., Kim, Sieun S., Lee, Seung-Jae V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2021
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477234/
https://www.ncbi.nlm.nih.gov/pubmed/34604714
http://dx.doi.org/10.17912/micropub.biology.000452
Descripción
Sumario:Y RNA is a conserved small non-coding RNA whose functions in aging remain unknown. Here, we sought to determine the role of C. elegans Y RNA homologs, CeY RNA (CeY) and stem-bulge RNAs (sbRNAs), in aging. We found that the levels of CeY and sbRNAs generally increased during aging. We showed that CeY was downregulated by oxidative and thermal stresses, whereas several sbRNAs were upregulated by oxidative stress. We did not observe lifespan phenotypes by mutations in CeY-coding yrn-1. Future research under various genetic and environmental conditions is required to further evaluate the role of Y RNA in C. elegans aging.

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