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Age-dependent upregulation of Y RNAs in Caenorhabditis elegans
Y RNA is a conserved small non-coding RNA whose functions in aging remain unknown. Here, we sought to determine the role of C. elegans Y RNA homologs, CeY RNA (CeY) and stem-bulge RNAs (sbRNAs), in aging. We found that the levels of CeY and sbRNAs generally increased during aging. We showed that CeY...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Caltech Library
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477234/ https://www.ncbi.nlm.nih.gov/pubmed/34604714 http://dx.doi.org/10.17912/micropub.biology.000452 |
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author | Park, Sangsoon Sohn, Jooyeon Kwon, Sujeong Kim, Eun Ji E Jung, Yoonji Park, Hae-Eun H. Kim, Sieun S. Lee, Seung-Jae V. |
author_facet | Park, Sangsoon Sohn, Jooyeon Kwon, Sujeong Kim, Eun Ji E Jung, Yoonji Park, Hae-Eun H. Kim, Sieun S. Lee, Seung-Jae V. |
author_sort | Park, Sangsoon |
collection | PubMed |
description | Y RNA is a conserved small non-coding RNA whose functions in aging remain unknown. Here, we sought to determine the role of C. elegans Y RNA homologs, CeY RNA (CeY) and stem-bulge RNAs (sbRNAs), in aging. We found that the levels of CeY and sbRNAs generally increased during aging. We showed that CeY was downregulated by oxidative and thermal stresses, whereas several sbRNAs were upregulated by oxidative stress. We did not observe lifespan phenotypes by mutations in CeY-coding yrn-1. Future research under various genetic and environmental conditions is required to further evaluate the role of Y RNA in C. elegans aging. |
format | Online Article Text |
id | pubmed-8477234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Caltech Library |
record_format | MEDLINE/PubMed |
spelling | pubmed-84772342021-09-30 Age-dependent upregulation of Y RNAs in Caenorhabditis elegans Park, Sangsoon Sohn, Jooyeon Kwon, Sujeong Kim, Eun Ji E Jung, Yoonji Park, Hae-Eun H. Kim, Sieun S. Lee, Seung-Jae V. MicroPubl Biol New Finding Y RNA is a conserved small non-coding RNA whose functions in aging remain unknown. Here, we sought to determine the role of C. elegans Y RNA homologs, CeY RNA (CeY) and stem-bulge RNAs (sbRNAs), in aging. We found that the levels of CeY and sbRNAs generally increased during aging. We showed that CeY was downregulated by oxidative and thermal stresses, whereas several sbRNAs were upregulated by oxidative stress. We did not observe lifespan phenotypes by mutations in CeY-coding yrn-1. Future research under various genetic and environmental conditions is required to further evaluate the role of Y RNA in C. elegans aging. Caltech Library 2021-09-27 /pmc/articles/PMC8477234/ /pubmed/34604714 http://dx.doi.org/10.17912/micropub.biology.000452 Text en Copyright: © 2021 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | New Finding Park, Sangsoon Sohn, Jooyeon Kwon, Sujeong Kim, Eun Ji E Jung, Yoonji Park, Hae-Eun H. Kim, Sieun S. Lee, Seung-Jae V. Age-dependent upregulation of Y RNAs in Caenorhabditis elegans |
title | Age-dependent upregulation of Y RNAs in Caenorhabditis elegans |
title_full | Age-dependent upregulation of Y RNAs in Caenorhabditis elegans |
title_fullStr | Age-dependent upregulation of Y RNAs in Caenorhabditis elegans |
title_full_unstemmed | Age-dependent upregulation of Y RNAs in Caenorhabditis elegans |
title_short | Age-dependent upregulation of Y RNAs in Caenorhabditis elegans |
title_sort | age-dependent upregulation of y rnas in caenorhabditis elegans |
topic | New Finding |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477234/ https://www.ncbi.nlm.nih.gov/pubmed/34604714 http://dx.doi.org/10.17912/micropub.biology.000452 |
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