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Age-dependent upregulation of Y RNAs in Caenorhabditis elegans

Y RNA is a conserved small non-coding RNA whose functions in aging remain unknown. Here, we sought to determine the role of C. elegans Y RNA homologs, CeY RNA (CeY) and stem-bulge RNAs (sbRNAs), in aging. We found that the levels of CeY and sbRNAs generally increased during aging. We showed that CeY...

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Autores principales: Park, Sangsoon, Sohn, Jooyeon, Kwon, Sujeong, Kim, Eun Ji E, Jung, Yoonji, Park, Hae-Eun H., Kim, Sieun S., Lee, Seung-Jae V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477234/
https://www.ncbi.nlm.nih.gov/pubmed/34604714
http://dx.doi.org/10.17912/micropub.biology.000452
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author Park, Sangsoon
Sohn, Jooyeon
Kwon, Sujeong
Kim, Eun Ji E
Jung, Yoonji
Park, Hae-Eun H.
Kim, Sieun S.
Lee, Seung-Jae V.
author_facet Park, Sangsoon
Sohn, Jooyeon
Kwon, Sujeong
Kim, Eun Ji E
Jung, Yoonji
Park, Hae-Eun H.
Kim, Sieun S.
Lee, Seung-Jae V.
author_sort Park, Sangsoon
collection PubMed
description Y RNA is a conserved small non-coding RNA whose functions in aging remain unknown. Here, we sought to determine the role of C. elegans Y RNA homologs, CeY RNA (CeY) and stem-bulge RNAs (sbRNAs), in aging. We found that the levels of CeY and sbRNAs generally increased during aging. We showed that CeY was downregulated by oxidative and thermal stresses, whereas several sbRNAs were upregulated by oxidative stress. We did not observe lifespan phenotypes by mutations in CeY-coding yrn-1. Future research under various genetic and environmental conditions is required to further evaluate the role of Y RNA in C. elegans aging.
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spelling pubmed-84772342021-09-30 Age-dependent upregulation of Y RNAs in Caenorhabditis elegans Park, Sangsoon Sohn, Jooyeon Kwon, Sujeong Kim, Eun Ji E Jung, Yoonji Park, Hae-Eun H. Kim, Sieun S. Lee, Seung-Jae V. MicroPubl Biol New Finding Y RNA is a conserved small non-coding RNA whose functions in aging remain unknown. Here, we sought to determine the role of C. elegans Y RNA homologs, CeY RNA (CeY) and stem-bulge RNAs (sbRNAs), in aging. We found that the levels of CeY and sbRNAs generally increased during aging. We showed that CeY was downregulated by oxidative and thermal stresses, whereas several sbRNAs were upregulated by oxidative stress. We did not observe lifespan phenotypes by mutations in CeY-coding yrn-1. Future research under various genetic and environmental conditions is required to further evaluate the role of Y RNA in C. elegans aging. Caltech Library 2021-09-27 /pmc/articles/PMC8477234/ /pubmed/34604714 http://dx.doi.org/10.17912/micropub.biology.000452 Text en Copyright: © 2021 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Park, Sangsoon
Sohn, Jooyeon
Kwon, Sujeong
Kim, Eun Ji E
Jung, Yoonji
Park, Hae-Eun H.
Kim, Sieun S.
Lee, Seung-Jae V.
Age-dependent upregulation of Y RNAs in Caenorhabditis elegans
title Age-dependent upregulation of Y RNAs in Caenorhabditis elegans
title_full Age-dependent upregulation of Y RNAs in Caenorhabditis elegans
title_fullStr Age-dependent upregulation of Y RNAs in Caenorhabditis elegans
title_full_unstemmed Age-dependent upregulation of Y RNAs in Caenorhabditis elegans
title_short Age-dependent upregulation of Y RNAs in Caenorhabditis elegans
title_sort age-dependent upregulation of y rnas in caenorhabditis elegans
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477234/
https://www.ncbi.nlm.nih.gov/pubmed/34604714
http://dx.doi.org/10.17912/micropub.biology.000452
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