Pinofuranoxins A and B, Bioactive Trisubstituted Furanones Produced by the Invasive Pathogen Diplodia sapinea

[Image: see text] Two new bioactive trisubstituted furanones, named pinofuranoxins A and B (1 and 2), were isolated from Diplodia sapinea, a worldwide conifer pathogen causing severe disease. Pinofuranoxins A and B were characterized essentially by NMR and HRESIMS spectra, and their relative and abs...

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Autores principales: Masi, Marco, Di Lecce, Roberta, Marsico, Giulia, Linaldeddu, Benedetto Teodoro, Maddau, Lucia, Superchi, Stefano, Evidente, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477388/
https://www.ncbi.nlm.nih.gov/pubmed/34469140
http://dx.doi.org/10.1021/acs.jnatprod.1c00365
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author Masi, Marco
Di Lecce, Roberta
Marsico, Giulia
Linaldeddu, Benedetto Teodoro
Maddau, Lucia
Superchi, Stefano
Evidente, Antonio
author_facet Masi, Marco
Di Lecce, Roberta
Marsico, Giulia
Linaldeddu, Benedetto Teodoro
Maddau, Lucia
Superchi, Stefano
Evidente, Antonio
author_sort Masi, Marco
collection PubMed
description [Image: see text] Two new bioactive trisubstituted furanones, named pinofuranoxins A and B (1 and 2), were isolated from Diplodia sapinea, a worldwide conifer pathogen causing severe disease. Pinofuranoxins A and B were characterized essentially by NMR and HRESIMS spectra, and their relative and absolute configurations were assigned by NOESY experiments and computational analyses of electronic circular dichroism spectra. They induced necrotic lesions on Hedera helix L., Phaseolus vulgaris L., and Quercus ilex L. Compound 1 completely inhibited the growth of Athelia rolfsii and Phytophthora cambivora, while 2 showed antioomycetes activity against P. cambivora. In the Artemia salina assay both toxins showed activity inducing larval mortality.
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spelling pubmed-84773882021-09-29 Pinofuranoxins A and B, Bioactive Trisubstituted Furanones Produced by the Invasive Pathogen Diplodia sapinea Masi, Marco Di Lecce, Roberta Marsico, Giulia Linaldeddu, Benedetto Teodoro Maddau, Lucia Superchi, Stefano Evidente, Antonio J Nat Prod [Image: see text] Two new bioactive trisubstituted furanones, named pinofuranoxins A and B (1 and 2), were isolated from Diplodia sapinea, a worldwide conifer pathogen causing severe disease. Pinofuranoxins A and B were characterized essentially by NMR and HRESIMS spectra, and their relative and absolute configurations were assigned by NOESY experiments and computational analyses of electronic circular dichroism spectra. They induced necrotic lesions on Hedera helix L., Phaseolus vulgaris L., and Quercus ilex L. Compound 1 completely inhibited the growth of Athelia rolfsii and Phytophthora cambivora, while 2 showed antioomycetes activity against P. cambivora. In the Artemia salina assay both toxins showed activity inducing larval mortality. American Chemical Society and American Society of Pharmacognosy 2021-09-01 2021-09-24 /pmc/articles/PMC8477388/ /pubmed/34469140 http://dx.doi.org/10.1021/acs.jnatprod.1c00365 Text en © 2021 The Authors. Published by American Chemical Society and American Society of Pharmacognosy https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Masi, Marco
Di Lecce, Roberta
Marsico, Giulia
Linaldeddu, Benedetto Teodoro
Maddau, Lucia
Superchi, Stefano
Evidente, Antonio
Pinofuranoxins A and B, Bioactive Trisubstituted Furanones Produced by the Invasive Pathogen Diplodia sapinea
title Pinofuranoxins A and B, Bioactive Trisubstituted Furanones Produced by the Invasive Pathogen Diplodia sapinea
title_full Pinofuranoxins A and B, Bioactive Trisubstituted Furanones Produced by the Invasive Pathogen Diplodia sapinea
title_fullStr Pinofuranoxins A and B, Bioactive Trisubstituted Furanones Produced by the Invasive Pathogen Diplodia sapinea
title_full_unstemmed Pinofuranoxins A and B, Bioactive Trisubstituted Furanones Produced by the Invasive Pathogen Diplodia sapinea
title_short Pinofuranoxins A and B, Bioactive Trisubstituted Furanones Produced by the Invasive Pathogen Diplodia sapinea
title_sort pinofuranoxins a and b, bioactive trisubstituted furanones produced by the invasive pathogen diplodia sapinea
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477388/
https://www.ncbi.nlm.nih.gov/pubmed/34469140
http://dx.doi.org/10.1021/acs.jnatprod.1c00365
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