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Dysregulated clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in amyloid precursor protein transgenic mice

Patients with Alzheimer’s disease (AD) often have fragmentation of sleep/wake cycles and disrupted 24-h (circadian) activity. Despite this, little work has investigated the potential underlying day/night disruptions in cognition and neuronal physiology in the hippocampus. The molecular clock, an int...

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Detalles Bibliográficos
Autores principales:	Fusilier, Allison R., Davis, Jennifer A., Paul, Jodi R., Yates, Stefani D., McMeekin, Laura J., Goode, Lacy K., Mokashi, Mugdha V., Remiszewski, Natalie, van Groen, Thomas, Cowell, Rita M., McMahon, Lori L., Roberson, Erik D., Gamble, Karen L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477442/ https://www.ncbi.nlm.nih.gov/pubmed/34333153 http://dx.doi.org/10.1016/j.nbd.2021.105454

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