Ultrafast 2D (1)H–(1)H NMR spectroscopy of DNP-hyperpolarised substrates for the analysis of mixtures

We show that TOCSY and multiple-quantum (MQ) 2D NMR spectra can be obtained for mixtures of substrates hyperpolarised by dissolution dynamic nuclear polarisation (D-DNP). This is achieved by combining optimised transfer settings for D-DNP, with ultrafast 2D NMR experiments based on spatiotemporal en...

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Detalles Bibliográficos
Autores principales: Singh, Kawarpal, Jacquemmoz, Corentin, Giraudeau, Patrick, Frydman, Lucio, Dumez, Jean-Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477446/
https://www.ncbi.nlm.nih.gov/pubmed/34291258
http://dx.doi.org/10.1039/d1cc03079e
Descripción
Sumario:We show that TOCSY and multiple-quantum (MQ) 2D NMR spectra can be obtained for mixtures of substrates hyperpolarised by dissolution dynamic nuclear polarisation (D-DNP). This is achieved by combining optimised transfer settings for D-DNP, with ultrafast 2D NMR experiments based on spatiotemporal encoding. TOCSY and MQ experiments are particularly well suited for mixture analysis, and this approach opens the way to significant sensitivity gains for analytical applications of NMR, such as authentication and metabolomics.

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