Ultrafast 2D (1)H–(1)H NMR spectroscopy of DNP-hyperpolarised substrates for the analysis of mixtures

We show that TOCSY and multiple-quantum (MQ) 2D NMR spectra can be obtained for mixtures of substrates hyperpolarised by dissolution dynamic nuclear polarisation (D-DNP). This is achieved by combining optimised transfer settings for D-DNP, with ultrafast 2D NMR experiments based on spatiotemporal en...

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Autores principales: Singh, Kawarpal, Jacquemmoz, Corentin, Giraudeau, Patrick, Frydman, Lucio, Dumez, Jean-Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477446/
https://www.ncbi.nlm.nih.gov/pubmed/34291258
http://dx.doi.org/10.1039/d1cc03079e
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author Singh, Kawarpal
Jacquemmoz, Corentin
Giraudeau, Patrick
Frydman, Lucio
Dumez, Jean-Nicolas
author_facet Singh, Kawarpal
Jacquemmoz, Corentin
Giraudeau, Patrick
Frydman, Lucio
Dumez, Jean-Nicolas
author_sort Singh, Kawarpal
collection PubMed
description We show that TOCSY and multiple-quantum (MQ) 2D NMR spectra can be obtained for mixtures of substrates hyperpolarised by dissolution dynamic nuclear polarisation (D-DNP). This is achieved by combining optimised transfer settings for D-DNP, with ultrafast 2D NMR experiments based on spatiotemporal encoding. TOCSY and MQ experiments are particularly well suited for mixture analysis, and this approach opens the way to significant sensitivity gains for analytical applications of NMR, such as authentication and metabolomics.
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spelling pubmed-84774462021-10-01 Ultrafast 2D (1)H–(1)H NMR spectroscopy of DNP-hyperpolarised substrates for the analysis of mixtures Singh, Kawarpal Jacquemmoz, Corentin Giraudeau, Patrick Frydman, Lucio Dumez, Jean-Nicolas Chem Commun (Camb) Chemistry We show that TOCSY and multiple-quantum (MQ) 2D NMR spectra can be obtained for mixtures of substrates hyperpolarised by dissolution dynamic nuclear polarisation (D-DNP). This is achieved by combining optimised transfer settings for D-DNP, with ultrafast 2D NMR experiments based on spatiotemporal encoding. TOCSY and MQ experiments are particularly well suited for mixture analysis, and this approach opens the way to significant sensitivity gains for analytical applications of NMR, such as authentication and metabolomics. The Royal Society of Chemistry 2021-07-15 /pmc/articles/PMC8477446/ /pubmed/34291258 http://dx.doi.org/10.1039/d1cc03079e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Singh, Kawarpal
Jacquemmoz, Corentin
Giraudeau, Patrick
Frydman, Lucio
Dumez, Jean-Nicolas
Ultrafast 2D (1)H–(1)H NMR spectroscopy of DNP-hyperpolarised substrates for the analysis of mixtures
title Ultrafast 2D (1)H–(1)H NMR spectroscopy of DNP-hyperpolarised substrates for the analysis of mixtures
title_full Ultrafast 2D (1)H–(1)H NMR spectroscopy of DNP-hyperpolarised substrates for the analysis of mixtures
title_fullStr Ultrafast 2D (1)H–(1)H NMR spectroscopy of DNP-hyperpolarised substrates for the analysis of mixtures
title_full_unstemmed Ultrafast 2D (1)H–(1)H NMR spectroscopy of DNP-hyperpolarised substrates for the analysis of mixtures
title_short Ultrafast 2D (1)H–(1)H NMR spectroscopy of DNP-hyperpolarised substrates for the analysis of mixtures
title_sort ultrafast 2d (1)h–(1)h nmr spectroscopy of dnp-hyperpolarised substrates for the analysis of mixtures
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477446/
https://www.ncbi.nlm.nih.gov/pubmed/34291258
http://dx.doi.org/10.1039/d1cc03079e
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