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SIRPα-αCD123 fusion antibodies targeting CD123 in conjunction with CD47 blockade enhance the clearance of AML-initiating cells

BACKGROUND: Acute myeloid leukaemia (AML) stem cells (LSCs) cause disease relapse. The CD47 “don’t eat me signal” is upregulated on LSCs and contributes to immune evasion by inhibiting phagocytosis through interacting with myeloid-specific signal regulatory protein alpha (SIRPα). Activation of macro...

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Detalles Bibliográficos
Autores principales:	Tahk, Siret, Vick, Binje, Hiller, Björn, Schmitt, Saskia, Marcinek, Anetta, Perini, Enrico D., Leutbecher, Alexandra, Augsberger, Christian, Reischer, Anna, Tast, Benjamin, Humpe, Andreas, Jeremias, Irmela, Subklewe, Marion, Fenn, Nadja C., Hopfner, Karl-Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477557/ https://www.ncbi.nlm.nih.gov/pubmed/34579739 http://dx.doi.org/10.1186/s13045-021-01163-6

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