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Investigation of MBL2 and NOS3 functional gene variants in suspected COVID-19 PCR (–) patients
For COVID-19 (Coronavirus Disease-2019) cases, detecting host-based factors that predispose to infection is a very important research area. In this study, the aim is to investigate the MBL2 and NOS3 gene polymorphisms in COVID-19 patients with lung involvement, whose first nasopharyngeal PCR results...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477587/ https://www.ncbi.nlm.nih.gov/pubmed/34570692 http://dx.doi.org/10.1080/20477724.2021.1984726 |
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author | Pehlivan, Sacide Köse, Murat Mese, Sevim Serin, Istemi Senkal, Naci Oyacı, Yasemin Medetalibeyoglu, Alpay Pehlivan, Mustafa Sayın, Gözde Yesil Isoglu-Alkac, Ummihan Tukek, Tufan |
author_facet | Pehlivan, Sacide Köse, Murat Mese, Sevim Serin, Istemi Senkal, Naci Oyacı, Yasemin Medetalibeyoglu, Alpay Pehlivan, Mustafa Sayın, Gözde Yesil Isoglu-Alkac, Ummihan Tukek, Tufan |
author_sort | Pehlivan, Sacide |
collection | PubMed |
description | For COVID-19 (Coronavirus Disease-2019) cases, detecting host-based factors that predispose to infection is a very important research area. In this study, the aim is to investigate the MBL2 and NOS3 gene polymorphisms in COVID-19 patients with lung involvement, whose first nasopharyngeal PCR results were negative. Seventy-nine patients diagnosed with COVID-19 between April-June 2020 who were admitted to a university hospital, and 100 healthy controls were included. In the first statistical analysis performed between PCR-positive, CT-negative and PCR-negative, CT-positive patients; the AB of MBL2 genotype was significantly higher in the first group (p = 0.049). The B allele was also significantly higher in the same subgroup (p = 0.001). The absence of the AB genotype was found to increase the risk of CT positivity by 6.9 times. The AB genotype of MBL2 was higher in healthy controls (p = 0.006). The absence of the AB genotype was found to increase the risk of CT positivity; also, it can be used for early detection and isolation of patients with typical lung involvement who had enough viral loads, but whose initial PCR results were negative. |
format | Online Article Text |
id | pubmed-8477587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-84775872021-09-29 Investigation of MBL2 and NOS3 functional gene variants in suspected COVID-19 PCR (–) patients Pehlivan, Sacide Köse, Murat Mese, Sevim Serin, Istemi Senkal, Naci Oyacı, Yasemin Medetalibeyoglu, Alpay Pehlivan, Mustafa Sayın, Gözde Yesil Isoglu-Alkac, Ummihan Tukek, Tufan Pathog Glob Health Research Article For COVID-19 (Coronavirus Disease-2019) cases, detecting host-based factors that predispose to infection is a very important research area. In this study, the aim is to investigate the MBL2 and NOS3 gene polymorphisms in COVID-19 patients with lung involvement, whose first nasopharyngeal PCR results were negative. Seventy-nine patients diagnosed with COVID-19 between April-June 2020 who were admitted to a university hospital, and 100 healthy controls were included. In the first statistical analysis performed between PCR-positive, CT-negative and PCR-negative, CT-positive patients; the AB of MBL2 genotype was significantly higher in the first group (p = 0.049). The B allele was also significantly higher in the same subgroup (p = 0.001). The absence of the AB genotype was found to increase the risk of CT positivity by 6.9 times. The AB genotype of MBL2 was higher in healthy controls (p = 0.006). The absence of the AB genotype was found to increase the risk of CT positivity; also, it can be used for early detection and isolation of patients with typical lung involvement who had enough viral loads, but whose initial PCR results were negative. Taylor & Francis 2021-09-27 /pmc/articles/PMC8477587/ /pubmed/34570692 http://dx.doi.org/10.1080/20477724.2021.1984726 Text en © 2021 Informa UK Limited, trading as Taylor & Francis Group |
spellingShingle | Research Article Pehlivan, Sacide Köse, Murat Mese, Sevim Serin, Istemi Senkal, Naci Oyacı, Yasemin Medetalibeyoglu, Alpay Pehlivan, Mustafa Sayın, Gözde Yesil Isoglu-Alkac, Ummihan Tukek, Tufan Investigation of MBL2 and NOS3 functional gene variants in suspected COVID-19 PCR (–) patients |
title | Investigation of MBL2 and NOS3 functional gene variants in suspected COVID-19 PCR (–) patients |
title_full | Investigation of MBL2 and NOS3 functional gene variants in suspected COVID-19 PCR (–) patients |
title_fullStr | Investigation of MBL2 and NOS3 functional gene variants in suspected COVID-19 PCR (–) patients |
title_full_unstemmed | Investigation of MBL2 and NOS3 functional gene variants in suspected COVID-19 PCR (–) patients |
title_short | Investigation of MBL2 and NOS3 functional gene variants in suspected COVID-19 PCR (–) patients |
title_sort | investigation of mbl2 and nos3 functional gene variants in suspected covid-19 pcr (–) patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477587/ https://www.ncbi.nlm.nih.gov/pubmed/34570692 http://dx.doi.org/10.1080/20477724.2021.1984726 |
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