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Frailty in inflammatory bowel diseases: an emerging concept
Inflammatory bowel diseases (IBD), consisting of Crohn’s disease and ulcerative colitis, are chronic remitting, relapsing inflammatory conditions of the gastrointestinal tract. While traditionally a disease of younger ages, the number of older adults with IBD is rising rapidly. Patients with IBD oft...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477705/ https://www.ncbi.nlm.nih.gov/pubmed/34594400 http://dx.doi.org/10.1177/17562848211025474 |
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author | Kochar, Bharati Orkaby, Ariela R. Ananthakrishnan, Ashwin N. Ritchie, Christine S. |
author_facet | Kochar, Bharati Orkaby, Ariela R. Ananthakrishnan, Ashwin N. Ritchie, Christine S. |
author_sort | Kochar, Bharati |
collection | PubMed |
description | Inflammatory bowel diseases (IBD), consisting of Crohn’s disease and ulcerative colitis, are chronic remitting, relapsing inflammatory conditions of the gastrointestinal tract. While traditionally a disease of younger ages, the number of older adults with IBD is rising rapidly. Patients with IBD often experience geriatric syndromes at earlier ages. Older adults with IBD have poorer disease and treatment-related outcomes compared with younger adults with IBD. Applying the principles of geriatrics to understanding a chronic disease in older adults may improve health span. Better tools are needed to stratify IBD patients who are at high risk for adverse events. Frailty is a geriatric construct that may approximate biologic age. Frailty is a complex, multi-dimensional syndrome that leads to increased vulnerability to stress and decline of reserve across multiple physiologic systems. In this review, we present the leading conceptual models of frailty and discuss the applications of frailty in immune-mediated diseases. We also review chronic conditions where frailty has been applied successfully as a tool for risk stratification. Finally, we discuss in the detail the growing body of literature highlighting the relationship between frailty and IBD, the epidemiology of frailty in IBD, and ramifications of frailty in IBD. |
format | Online Article Text |
id | pubmed-8477705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-84777052021-09-29 Frailty in inflammatory bowel diseases: an emerging concept Kochar, Bharati Orkaby, Ariela R. Ananthakrishnan, Ashwin N. Ritchie, Christine S. Therap Adv Gastroenterol Review Inflammatory bowel diseases (IBD), consisting of Crohn’s disease and ulcerative colitis, are chronic remitting, relapsing inflammatory conditions of the gastrointestinal tract. While traditionally a disease of younger ages, the number of older adults with IBD is rising rapidly. Patients with IBD often experience geriatric syndromes at earlier ages. Older adults with IBD have poorer disease and treatment-related outcomes compared with younger adults with IBD. Applying the principles of geriatrics to understanding a chronic disease in older adults may improve health span. Better tools are needed to stratify IBD patients who are at high risk for adverse events. Frailty is a geriatric construct that may approximate biologic age. Frailty is a complex, multi-dimensional syndrome that leads to increased vulnerability to stress and decline of reserve across multiple physiologic systems. In this review, we present the leading conceptual models of frailty and discuss the applications of frailty in immune-mediated diseases. We also review chronic conditions where frailty has been applied successfully as a tool for risk stratification. Finally, we discuss in the detail the growing body of literature highlighting the relationship between frailty and IBD, the epidemiology of frailty in IBD, and ramifications of frailty in IBD. SAGE Publications 2021-09-24 /pmc/articles/PMC8477705/ /pubmed/34594400 http://dx.doi.org/10.1177/17562848211025474 Text en © The Author(s), 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Kochar, Bharati Orkaby, Ariela R. Ananthakrishnan, Ashwin N. Ritchie, Christine S. Frailty in inflammatory bowel diseases: an emerging concept |
title | Frailty in inflammatory bowel diseases: an emerging concept |
title_full | Frailty in inflammatory bowel diseases: an emerging concept |
title_fullStr | Frailty in inflammatory bowel diseases: an emerging concept |
title_full_unstemmed | Frailty in inflammatory bowel diseases: an emerging concept |
title_short | Frailty in inflammatory bowel diseases: an emerging concept |
title_sort | frailty in inflammatory bowel diseases: an emerging concept |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477705/ https://www.ncbi.nlm.nih.gov/pubmed/34594400 http://dx.doi.org/10.1177/17562848211025474 |
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