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Extra-axial Desmoplastic Medulloblastoma in Adult Cerebellopontine Angle: Case Report and Noninvasive Molecular Subgrouping Utilizing Magnetic Resonance Imaging-Based Radiomics Nomogram

Cerebellopontine angle (CPA) is an atypical site for adult medulloblastoma (MB) with only 12 cases reported in pure extra-axial location. None was predicted on preoperative imaging while the most common misdiagnosis was petrous meningioma. We add the 13(th) case to this list, attempting to reiterate...

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Autores principales: Ali, Sundus, Qasim, Adnan, Tasdique, Shahzaib, Sarwar, Muhammad Rizwan, Shams, Shahzad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477825/
https://www.ncbi.nlm.nih.gov/pubmed/34660382
http://dx.doi.org/10.4103/ajns.AJNS_525_20
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author Ali, Sundus
Qasim, Adnan
Tasdique, Shahzaib
Sarwar, Muhammad Rizwan
Shams, Shahzad
author_facet Ali, Sundus
Qasim, Adnan
Tasdique, Shahzaib
Sarwar, Muhammad Rizwan
Shams, Shahzad
author_sort Ali, Sundus
collection PubMed
description Cerebellopontine angle (CPA) is an atypical site for adult medulloblastoma (MB) with only 12 cases reported in pure extra-axial location. None was predicted on preoperative imaging while the most common misdiagnosis was petrous meningioma. We add the 13(th) case to this list, attempting to reiterate the radiological features for preoperative prediction of this rare pathology on conventional magnetic resonance imaging (MRI). Molecular subtyping also is not yet reported for adult extra-axial CPA MB. We propose the routine use of MRI-based nomograms, in atypical CPA extra-axial masses, for noninvasive prediction of molecular subgroup, especially in resource-limited setups that lack the facility of genetic profiling.
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spelling pubmed-84778252021-10-14 Extra-axial Desmoplastic Medulloblastoma in Adult Cerebellopontine Angle: Case Report and Noninvasive Molecular Subgrouping Utilizing Magnetic Resonance Imaging-Based Radiomics Nomogram Ali, Sundus Qasim, Adnan Tasdique, Shahzaib Sarwar, Muhammad Rizwan Shams, Shahzad Asian J Neurosurg Case Report Cerebellopontine angle (CPA) is an atypical site for adult medulloblastoma (MB) with only 12 cases reported in pure extra-axial location. None was predicted on preoperative imaging while the most common misdiagnosis was petrous meningioma. We add the 13(th) case to this list, attempting to reiterate the radiological features for preoperative prediction of this rare pathology on conventional magnetic resonance imaging (MRI). Molecular subtyping also is not yet reported for adult extra-axial CPA MB. We propose the routine use of MRI-based nomograms, in atypical CPA extra-axial masses, for noninvasive prediction of molecular subgroup, especially in resource-limited setups that lack the facility of genetic profiling. Wolters Kluwer - Medknow 2021-09-14 /pmc/articles/PMC8477825/ /pubmed/34660382 http://dx.doi.org/10.4103/ajns.AJNS_525_20 Text en Copyright: © 2021 Asian Journal of Neurosurgery https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Ali, Sundus
Qasim, Adnan
Tasdique, Shahzaib
Sarwar, Muhammad Rizwan
Shams, Shahzad
Extra-axial Desmoplastic Medulloblastoma in Adult Cerebellopontine Angle: Case Report and Noninvasive Molecular Subgrouping Utilizing Magnetic Resonance Imaging-Based Radiomics Nomogram
title Extra-axial Desmoplastic Medulloblastoma in Adult Cerebellopontine Angle: Case Report and Noninvasive Molecular Subgrouping Utilizing Magnetic Resonance Imaging-Based Radiomics Nomogram
title_full Extra-axial Desmoplastic Medulloblastoma in Adult Cerebellopontine Angle: Case Report and Noninvasive Molecular Subgrouping Utilizing Magnetic Resonance Imaging-Based Radiomics Nomogram
title_fullStr Extra-axial Desmoplastic Medulloblastoma in Adult Cerebellopontine Angle: Case Report and Noninvasive Molecular Subgrouping Utilizing Magnetic Resonance Imaging-Based Radiomics Nomogram
title_full_unstemmed Extra-axial Desmoplastic Medulloblastoma in Adult Cerebellopontine Angle: Case Report and Noninvasive Molecular Subgrouping Utilizing Magnetic Resonance Imaging-Based Radiomics Nomogram
title_short Extra-axial Desmoplastic Medulloblastoma in Adult Cerebellopontine Angle: Case Report and Noninvasive Molecular Subgrouping Utilizing Magnetic Resonance Imaging-Based Radiomics Nomogram
title_sort extra-axial desmoplastic medulloblastoma in adult cerebellopontine angle: case report and noninvasive molecular subgrouping utilizing magnetic resonance imaging-based radiomics nomogram
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477825/
https://www.ncbi.nlm.nih.gov/pubmed/34660382
http://dx.doi.org/10.4103/ajns.AJNS_525_20
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