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Disseminated invasive aspergillosis caused by Aspergillus felis in a cat

A 2‐year‐old male desexed Ragdoll cat with a 1‐year history of sneezing and nasal discharge presented with a large subcutaneous cervical mass, identified as the right medial retropharyngeal lymph node on computed tomography (CT). A right orbital mass, destructive sino‐nasal cavity disease and multip...

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Autores principales: Cormack, Catherine A., Donahoe, Shannon L., Talbot, Jessica J., Beatty, Julia A., Barrs, Vanessa R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478040/
https://www.ncbi.nlm.nih.gov/pubmed/34414603
http://dx.doi.org/10.1111/jvim.16245
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author Cormack, Catherine A.
Donahoe, Shannon L.
Talbot, Jessica J.
Beatty, Julia A.
Barrs, Vanessa R.
author_facet Cormack, Catherine A.
Donahoe, Shannon L.
Talbot, Jessica J.
Beatty, Julia A.
Barrs, Vanessa R.
author_sort Cormack, Catherine A.
collection PubMed
description A 2‐year‐old male desexed Ragdoll cat with a 1‐year history of sneezing and nasal discharge presented with a large subcutaneous cervical mass, identified as the right medial retropharyngeal lymph node on computed tomography (CT). A right orbital mass, destructive sino‐nasal cavity disease and multiple pulmonary nodules were also identified. Aspergillus felis was cultured from the lymph node. After treatment with posaconazole and liposomal amphotericin B the lymph node enlargement and orbital mass resolved but left frontal sinus involvement and pulmonary lesions persisted despite additional caspofungin therapy. The cat was euthanized 14 months after diagnosis with dysphagia and chronic progressive exophthalmos. A meningeal granuloma with intravascular fungal hyphae was identified at post‐mortem and A felis was cultured from the left frontal sinus and a right retrobulbar fungal granuloma. This case demonstrates that disseminated disease is a possible sequel to invasive fungal rhinosinusitis caused by A felis in cats.
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spelling pubmed-84780402021-10-01 Disseminated invasive aspergillosis caused by Aspergillus felis in a cat Cormack, Catherine A. Donahoe, Shannon L. Talbot, Jessica J. Beatty, Julia A. Barrs, Vanessa R. J Vet Intern Med SMALL ANIMAL A 2‐year‐old male desexed Ragdoll cat with a 1‐year history of sneezing and nasal discharge presented with a large subcutaneous cervical mass, identified as the right medial retropharyngeal lymph node on computed tomography (CT). A right orbital mass, destructive sino‐nasal cavity disease and multiple pulmonary nodules were also identified. Aspergillus felis was cultured from the lymph node. After treatment with posaconazole and liposomal amphotericin B the lymph node enlargement and orbital mass resolved but left frontal sinus involvement and pulmonary lesions persisted despite additional caspofungin therapy. The cat was euthanized 14 months after diagnosis with dysphagia and chronic progressive exophthalmos. A meningeal granuloma with intravascular fungal hyphae was identified at post‐mortem and A felis was cultured from the left frontal sinus and a right retrobulbar fungal granuloma. This case demonstrates that disseminated disease is a possible sequel to invasive fungal rhinosinusitis caused by A felis in cats. John Wiley & Sons, Inc. 2021-08-20 2021 /pmc/articles/PMC8478040/ /pubmed/34414603 http://dx.doi.org/10.1111/jvim.16245 Text en © 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle SMALL ANIMAL
Cormack, Catherine A.
Donahoe, Shannon L.
Talbot, Jessica J.
Beatty, Julia A.
Barrs, Vanessa R.
Disseminated invasive aspergillosis caused by Aspergillus felis in a cat
title Disseminated invasive aspergillosis caused by Aspergillus felis in a cat
title_full Disseminated invasive aspergillosis caused by Aspergillus felis in a cat
title_fullStr Disseminated invasive aspergillosis caused by Aspergillus felis in a cat
title_full_unstemmed Disseminated invasive aspergillosis caused by Aspergillus felis in a cat
title_short Disseminated invasive aspergillosis caused by Aspergillus felis in a cat
title_sort disseminated invasive aspergillosis caused by aspergillus felis in a cat
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478040/
https://www.ncbi.nlm.nih.gov/pubmed/34414603
http://dx.doi.org/10.1111/jvim.16245
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