Gene-by-environment modulation of lifespan and weight gain in the murine BXD family

How lifespan and body weight vary as a function of diet and genetic differences is not well understood. Here we quantify the impact of differences in diet in a genetically diverse family of female mice, split into matched isogenic cohorts fed a low-fat chow (CD, n = 663) or a high-fat diet (HFD, n =...

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Detalles Bibliográficos
Autores principales: Roy, Suheeta, Sleiman, Maroun Bou, Jha, Pooja, Ingels, Jesse F., Chapman, Casey J., McCarty, Melinda S., Ziebarth, Jesse D., Hook, Michael, Sun, Anna, Zhao, Wenyuan, Huang, Jinsong, Neuner, Sarah M., Wilmott, Lynda A., Shapaker, Thomas M., Centeno, Arthur G., Ashbrook, David G., Mulligan, Megan K., Kaczorowski, Catherine C., Makowski, Liza, Cui, Yan, Read, Robert W., Miller, Richard A., Mozhui, Khyobeni, Williams, Evan G., Sen, Saunak, Lu, Lu, Auwerx, Johan, Williams, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478125/
https://www.ncbi.nlm.nih.gov/pubmed/34552269
http://dx.doi.org/10.1038/s42255-021-00449-w

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