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Dynamic modelling of the PI3K/MTOR signalling network uncovers biphasic dependence of mTORC1 activity on the mTORC2 subunit SIN1

The PI3K/MTOR signalling network regulates a broad array of critical cellular processes, including cell growth, metabolism and autophagy. The mechanistic target of rapamycin (MTOR) kinase functions as a core catalytic subunit in two physically and functionally distinct complexes mTORC1 and mTORC2, w...

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Detalles Bibliográficos
Autores principales:	Ghomlaghi, Milad, Yang, Guang, Shin, Sung-Young, James, David E., Nguyen, Lan K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478217/ https://www.ncbi.nlm.nih.gov/pubmed/34529665 http://dx.doi.org/10.1371/journal.pcbi.1008513

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