Biogenesis of P-TEFb in CD4(+) T cells to reverse HIV latency is mediated by protein kinase C (PKC)-independent signaling pathways

The switch between HIV latency and productive transcription is regulated by an auto-feedback mechanism initiated by the viral trans-activator Tat, which functions to recruit the host transcription elongation factor P-TEFb to proviral HIV. A heterodimeric complex of CDK9 and one of three cyclin T sub...

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Detalles Bibliográficos
Autores principales: Mbonye, Uri, Leskov, Konstantin, Shukla, Meenakshi, Valadkhan, Saba, Karn, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478230/
https://www.ncbi.nlm.nih.gov/pubmed/34529720
http://dx.doi.org/10.1371/journal.ppat.1009581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478230/
https://www.ncbi.nlm.nih.gov/pubmed/34529720
http://dx.doi.org/10.1371/journal.ppat.1009581

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