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Biogenesis of P-TEFb in CD4(+) T cells to reverse HIV latency is mediated by protein kinase C (PKC)-independent signaling pathways
The switch between HIV latency and productive transcription is regulated by an auto-feedback mechanism initiated by the viral trans-activator Tat, which functions to recruit the host transcription elongation factor P-TEFb to proviral HIV. A heterodimeric complex of CDK9 and one of three cyclin T sub...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478230/ https://www.ncbi.nlm.nih.gov/pubmed/34529720 http://dx.doi.org/10.1371/journal.ppat.1009581 |