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Current Alzheimer disease research highlights: evidence for novel risk factors

Alzheimer disease (AD) is the most common type of dementia characterized by the progressive cognitive and social decline. Clinical drug targets have heavily focused on the amyloid hypothesis, with amyloid beta (Aβ), and tau proteins as key pathophysiologic markers of AD. However, no effective treatm...

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Autores principales: Brenowitz, Willa D., Xiang, Yang, McEvoy, Claire T., Yang, Cui, Yaffe, Kristine, Le, Wei-Dong, Leng, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478399/
https://www.ncbi.nlm.nih.gov/pubmed/34507318
http://dx.doi.org/10.1097/CM9.0000000000001706
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author Brenowitz, Willa D.
Xiang, Yang
McEvoy, Claire T.
Yang, Cui
Yaffe, Kristine
Le, Wei-Dong
Leng, Yue
author_facet Brenowitz, Willa D.
Xiang, Yang
McEvoy, Claire T.
Yang, Cui
Yaffe, Kristine
Le, Wei-Dong
Leng, Yue
author_sort Brenowitz, Willa D.
collection PubMed
description Alzheimer disease (AD) is the most common type of dementia characterized by the progressive cognitive and social decline. Clinical drug targets have heavily focused on the amyloid hypothesis, with amyloid beta (Aβ), and tau proteins as key pathophysiologic markers of AD. However, no effective treatment has been developed so far, which prompts researchers to focus on other aspects of AD beyond Aβ, and tau proteins. Additionally, there is a mounting epidemiologic evidence that various environmental factors influence the development of dementia and that dementia etiology is likely heterogenous. In the past decades, new risk factors or potential etiologies have been widely studied. Here, we review several novel epidemiologic and clinical research developments that focus on sleep, hypoxia, diet, gut microbiota, and hearing impairment and their links to AD published in recent years. At the frontiers of AD research, these findings and updates could be worthy of further attention.
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spelling pubmed-84783992021-09-30 Current Alzheimer disease research highlights: evidence for novel risk factors Brenowitz, Willa D. Xiang, Yang McEvoy, Claire T. Yang, Cui Yaffe, Kristine Le, Wei-Dong Leng, Yue Chin Med J (Engl) Review Article Alzheimer disease (AD) is the most common type of dementia characterized by the progressive cognitive and social decline. Clinical drug targets have heavily focused on the amyloid hypothesis, with amyloid beta (Aβ), and tau proteins as key pathophysiologic markers of AD. However, no effective treatment has been developed so far, which prompts researchers to focus on other aspects of AD beyond Aβ, and tau proteins. Additionally, there is a mounting epidemiologic evidence that various environmental factors influence the development of dementia and that dementia etiology is likely heterogenous. In the past decades, new risk factors or potential etiologies have been widely studied. Here, we review several novel epidemiologic and clinical research developments that focus on sleep, hypoxia, diet, gut microbiota, and hearing impairment and their links to AD published in recent years. At the frontiers of AD research, these findings and updates could be worthy of further attention. Lippincott Williams & Wilkins 2021-09-20 2021-09-09 /pmc/articles/PMC8478399/ /pubmed/34507318 http://dx.doi.org/10.1097/CM9.0000000000001706 Text en Copyright © 2021 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Review Article
Brenowitz, Willa D.
Xiang, Yang
McEvoy, Claire T.
Yang, Cui
Yaffe, Kristine
Le, Wei-Dong
Leng, Yue
Current Alzheimer disease research highlights: evidence for novel risk factors
title Current Alzheimer disease research highlights: evidence for novel risk factors
title_full Current Alzheimer disease research highlights: evidence for novel risk factors
title_fullStr Current Alzheimer disease research highlights: evidence for novel risk factors
title_full_unstemmed Current Alzheimer disease research highlights: evidence for novel risk factors
title_short Current Alzheimer disease research highlights: evidence for novel risk factors
title_sort current alzheimer disease research highlights: evidence for novel risk factors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478399/
https://www.ncbi.nlm.nih.gov/pubmed/34507318
http://dx.doi.org/10.1097/CM9.0000000000001706
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