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A rare case of extraluminally pedunculated gastrointestinal stromal tumor with postoperative metastasis to pancreas
The gastrointestinal stromal tumor (GIST) is the most common type of sarcomatous tumor of the gastrointestinal tract. Many GISTs appear as submucosal tumors with intraluminal protrusion. GISTs with malignant features have a high risk of postoperative recurrence or metastasis, usually to the liver or...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478476/ https://www.ncbi.nlm.nih.gov/pubmed/34594492 http://dx.doi.org/10.1093/jscr/rjab422 |
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author | Ogawa, Shoko Nishihara, Masayoshi Nakanishi, Takaya Maeda, Tamaki Hirota, Seiichi |
author_facet | Ogawa, Shoko Nishihara, Masayoshi Nakanishi, Takaya Maeda, Tamaki Hirota, Seiichi |
author_sort | Ogawa, Shoko |
collection | PubMed |
description | The gastrointestinal stromal tumor (GIST) is the most common type of sarcomatous tumor of the gastrointestinal tract. Many GISTs appear as submucosal tumors with intraluminal protrusion. GISTs with malignant features have a high risk of postoperative recurrence or metastasis, usually to the liver or peritoneum. We present a case of gastric GIST with double rarities: arising completely extraluminally with a pedicle and postoperative metastasis to the pancreas. A woman in her seventies diagnosed with a large extraluminal gastric GIST underwent complete removal of the tumor. Nine months later, a solitary metastatic tumor in the pancreas was detected. Imatinib controlled metastasis well for four years before the tumor became resistant. The patient then had a partial pancreatectomy with splenectomy. She is currently free from recurrence. We genetically analyzed the primary and metastatic GISTs and found known mutations related to poor prognosis and imatinib resistance. |
format | Online Article Text |
id | pubmed-8478476 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-84784762021-09-29 A rare case of extraluminally pedunculated gastrointestinal stromal tumor with postoperative metastasis to pancreas Ogawa, Shoko Nishihara, Masayoshi Nakanishi, Takaya Maeda, Tamaki Hirota, Seiichi J Surg Case Rep Case Report The gastrointestinal stromal tumor (GIST) is the most common type of sarcomatous tumor of the gastrointestinal tract. Many GISTs appear as submucosal tumors with intraluminal protrusion. GISTs with malignant features have a high risk of postoperative recurrence or metastasis, usually to the liver or peritoneum. We present a case of gastric GIST with double rarities: arising completely extraluminally with a pedicle and postoperative metastasis to the pancreas. A woman in her seventies diagnosed with a large extraluminal gastric GIST underwent complete removal of the tumor. Nine months later, a solitary metastatic tumor in the pancreas was detected. Imatinib controlled metastasis well for four years before the tumor became resistant. The patient then had a partial pancreatectomy with splenectomy. She is currently free from recurrence. We genetically analyzed the primary and metastatic GISTs and found known mutations related to poor prognosis and imatinib resistance. Oxford University Press 2021-09-27 /pmc/articles/PMC8478476/ /pubmed/34594492 http://dx.doi.org/10.1093/jscr/rjab422 Text en Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2021. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Ogawa, Shoko Nishihara, Masayoshi Nakanishi, Takaya Maeda, Tamaki Hirota, Seiichi A rare case of extraluminally pedunculated gastrointestinal stromal tumor with postoperative metastasis to pancreas |
title | A rare case of extraluminally pedunculated gastrointestinal stromal tumor with postoperative metastasis to pancreas |
title_full | A rare case of extraluminally pedunculated gastrointestinal stromal tumor with postoperative metastasis to pancreas |
title_fullStr | A rare case of extraluminally pedunculated gastrointestinal stromal tumor with postoperative metastasis to pancreas |
title_full_unstemmed | A rare case of extraluminally pedunculated gastrointestinal stromal tumor with postoperative metastasis to pancreas |
title_short | A rare case of extraluminally pedunculated gastrointestinal stromal tumor with postoperative metastasis to pancreas |
title_sort | rare case of extraluminally pedunculated gastrointestinal stromal tumor with postoperative metastasis to pancreas |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478476/ https://www.ncbi.nlm.nih.gov/pubmed/34594492 http://dx.doi.org/10.1093/jscr/rjab422 |
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