Cargando…

High degree of conservation of the enzymes synthesizing the laminin-binding glycoepitope of α-dystroglycan

The dystroglycan (DG) complex plays a pivotal role for the stabilization of muscles in Metazoa. It is formed by two subunits, extracellular α-DG and transmembrane β-DG, originating from a unique precursor via a complex post-translational maturation process. The α-DG subunit is extensively glycosylat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bigotti, Maria Giulia, Brancaccio, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478517/ https://www.ncbi.nlm.nih.gov/pubmed/34582712 http://dx.doi.org/10.1098/rsob.210104

Ejemplares similares

Structural flexibility of human α‐dystroglycan
por: Covaceuszach, Sonia, et al.
Publicado: (2017)

Identification and Modeling of a GT-A Fold in the α-Dystroglycan Glycosylating Enzyme LARGE1
por: Righino, Benedetta, et al.
Publicado: (2020)

Analysis of α-Dystroglycan/LG Domain Binding Modes: Investigating Protein Motifs That Regulate the Affinity of Isolated LG Domains
por: Dempsey, Christopher E., et al.
Publicado: (2019)

Genetic Engineering of Dystroglycan in Animal Models of Muscular Dystrophy
por: Sciandra, Francesca, et al.
Publicado: (2015)

Structural basis of laminin binding to the LARGE glycans on dystroglycan
por: Briggs, David C., et al.
Publicado: (2016)

Insertion of a myc-tag within α-dystroglycan domains improves its biochemical and microscopic detection
por: Morlacchi, Simona, et al.
Publicado: (2012)

The Structure of the T190M Mutant of Murine α-Dystroglycan at High Resolution: Insight into the Molecular Basis of a Primary Dystroglycanopathy
por: Bozzi, Manuela, et al.
Publicado: (2015)

The effect of the pathological V72I, D109N and T190M missense mutations on the molecular structure of α-dystroglycan
por: Covaceuszach, Sonia, et al.
Publicado: (2017)

Loss of α-Dystroglycan Laminin Binding in Epithelium-derived Cancers Is Caused by Silencing of LARGE
por: de Bernabé, Daniel Beltrán-Valero, et al.
Publicado: (2009)

LARGE Expression Augments the Glycosylation of Glycoproteins in Addition to α-Dystroglycan Conferring Laminin Binding
por: Zhang, Zhen, et al.
Publicado: (2011)

Exogenous expression of the glycosyltransferase LARGE1 restores α-dystroglycan matriglycan and laminin binding in rhabdomyosarcoma
por: Beltrán, Daniel, et al.
Publicado: (2019)

Evaluation of the effect of a floxed Neo cassette within the dystroglycan (Dag1) gene
por: Sciandra, Francesca, et al.
Publicado: (2017)

Linker molecules between laminins and dystroglycan ameliorate laminin-α2–deficient muscular dystrophy at all disease stages
por: Meinen, Sarina, et al.
Publicado: (2007)

An evaluation of the evolution of the gene structure of dystroglycan
por: Brancaccio, Andrea, et al.
Publicado: (2017)

Residual laminin-binding activity and enhanced dystroglycan glycosylation by LARGE in novel model mice to dystroglycanopathy
por: Kanagawa, Motoi, et al.
Publicado: (2009)

Exogenous laminin exhibits a unique vascular pattern in the brain via binding to dystroglycan and integrins
por: Ruan, Jingsong, et al.
Publicado: (2022)

Paucimannosidic glycoepitopes inhibit tumorigenic processes in glioblastoma multiforme
por: Becker, Yvonne, et al.
Publicado: (2019)

An atypical expression of core α-Dystroglycan and Laminin-α2 in skin fibroblasts of patients with congenital muscular dystrophies
por: Sabry, Sahar, et al.
Publicado: (2023)

The conserved WW-domain binding sites in Dystroglycan C-terminus are essential but partially redundant for Dystroglycan function
por: Yatsenko, AS, et al.
Publicado: (2009)

α-Dystroglycan Is a Laminin Receptor Involved in Extracellular Matrix Assembly on Myotubes and Muscle Cell Viability
por: Montanaro, Federica, et al.
Publicado: (1999)

Conserved topology of virus glycoepitopes presents novel targets for repurposing HIV antibody 2G12
por: Miller, Nathaniel L., et al.
Publicado: (2022)

Probing the stability of the “naked” mucin-like domain of human α-dystroglycan
por: Bozzi, Manuela, et al.
Publicado: (2013)

biAb Mediated Restoration of the Linkage between Dystroglycan and Laminin-211 as a Therapeutic Approach for α-Dystroglycanopathies
por: Gumlaw, Nathan, et al.
Publicado: (2020)

Characterization of dystroglycan binding in adhesion of human induced pluripotent stem cells to laminin-511 E8 fragment
por: Sugawara, Yumika, et al.
Publicado: (2019)

The evolution of the dystroglycan complex, a major mediator of muscle integrity
por: Adams, Josephine C., et al.
Publicado: (2015)

M. leprae interacts with the human epidermal keratinocytes, neonatal (HEKn) via the binding of laminin-5 with α-dystroglycan, integrin-β1, or -β4
por: Jin, Song-Hyo, et al.
Publicado: (2019)

Laminin-induced Clustering of Dystroglycan on Embryonic Muscle Cells: Comparison with Agrin-induced Clustering
por: Cohen, Monroe W., et al.
Publicado: (1997)

Duplication of the dystroglycan gene in most branches of teleost fish
por: Pavoni, Ernesto, et al.
Publicado: (2007)

Xylosyl- and glucuronyltransferase functions of LARGE in α-dystroglycan modification are conserved in LARGE2
por: Inamori, Kei-ichiro, et al.
Publicado: (2013)

Dystroglycan is associated to the disulfide isomerase ERp57
por: Sciandra, Francesca, et al.
Publicado: (2012)

Dystroglycan Binding to α-Neurexin Competes with Neurexophilin-1 and Neuroligin in the Brain
por: Reissner, Carsten, et al.
Publicado: (2014)

Cerebral Organoids Maintain the Expression of Neural Stem Cell-Associated Glycoepitopes and Extracellular Matrix
por: Roll, Lars, et al.
Publicado: (2022)

A High Throughput Screen Identifies Chemical Modulators of the Laminin-Induced Clustering of Dystroglycan and Aquaporin-4 in Primary Astrocytes
por: Noël, Geoffroy, et al.
Publicado: (2011)

Lectin-Based Study Reveals the Presence of Disease-Relevant Glycoepitopes in Bladder Cancer Cells and Ectosomes
por: Surman, Magdalena, et al.
Publicado: (2022)

The enzymatic processing of α-dystroglycan by MMP-2 is controlled by two anchoring sites distinct from the active site
por: Gioia, Magda, et al.
Publicado: (2018)

B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycan
por: Praissman, Jeremy L, et al.
Publicado: (2014)

N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy
por: Okuma, Hidehiko, et al.
Publicado: (2023)

α-5 Laminin Synthesized by Human Pluripotent Stem Cells Promotes Self-Renewal
por: Laperle, Alex, et al.
Publicado: (2015)

Identification of Matriglycan by Dual Exoglycosidase Digestion of α-Dystroglycan
por: Chandel, Ishita, et al.
Publicado: (2023)

The Small Leucine-Rich Repeat Proteoglycan Biglycan Binds to α-Dystroglycan and Is Upregulated in Dystrophic Muscle
por: Bowe, Mark A., et al.
Publicado: (2000)

Cannot write session to /tmp/vufind_sessions/sess_ktp737dombd2q4pimhutoo1ij9