CXCR4 hyperactivation cooperates with TCL1 in CLL development and aggressiveness

Aberrant CXCR4 activity has been implicated in lymphoma pathogenesis, disease progression, and resistance to therapies. Using a mouse model with a gain-of-function CXCR4 mutation (CXCR4(C1013G)) that hyperactivates CXCR4 signaling, we identified CXCR4 as a crucial activator of multiple key oncogenic...

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Detalles Bibliográficos
Autores principales: Lewis, Richard, Maurer, H. Carlo, Singh, Nikita, Gonzalez-Menendez, Irene, Wirth, Matthias, Schick, Markus, Zhang, Le, Isaakidis, Konstandina, Scherger, Anna Katharina, Schulze, Veronika, Lu, Junyan, Zenz, Thorsten, Steiger, Katja, Rad, Roland, Quintanilla-Martinez, Leticia, Espeli, Marion, Balabanian, Karl, Keller, Ulrich, Habringer, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478649/
https://www.ncbi.nlm.nih.gov/pubmed/34363012
http://dx.doi.org/10.1038/s41375-021-01376-1

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