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Systematic in silico analysis of clinically tested drugs for reducing amyloid‐beta plaque accumulation in Alzheimer's disease

INTRODUCTION: Despite strong evidence linking amyloid beta (Aβ) to Alzheimer's disease, most clinical trials have shown no clinical efficacy for reasons that remain unclear. To understand why, we developed a quantitative systems pharmacology (QSP) model for seven therapeutics: aducanumab, crene...

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Detalles Bibliográficos
Autores principales:	Madrasi, Kumpal, Das, Raibatak, Mohmmadabdul, Hafiz, Lin, Lin, Hyman, Bradley T., Lauffenburger, Douglas A., Albers, Mark W., Rissman, Robert A., Burke, John M., Apgar, Joshua F., Wille, Lucia, Gruenbaum, Lore, Hua, Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478725/ https://www.ncbi.nlm.nih.gov/pubmed/33938131 http://dx.doi.org/10.1002/alz.12312

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