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Prospective cohort study of children exposed to Hepatitis C virus through a pregnancy screening program

OBJECTIVES: Porto Alegre, in south Brazil, has one of the highest Hepatitis C virus (HCV) infections rate in the country (84.4 cases/100,000 in 2018). Prenatal screening of HCV, however, has not been routinely offered. METHODS: We conducted a longitudinal study of pregnant women with HCV and their i...

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Autores principales: Pinto, Raquel Borges, Ramos, Ana Regina L., Padua, Leidy Tovar, Swayze, Emma Jane, Cambou, Mary Catherine, Fiorini, Maristela, Melo, Marineide, Santos, Breno Riegel, Teixeira Canti, Ivete Cristina, Rieck Silveira, Mara Liane, Gonzalez Solari, Maria Inês, de Correa, Juliana Ferraz, Chew, Kara, dos Santos Varella, Ivana Rosângela, Nielsen-Saines, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478836/
https://www.ncbi.nlm.nih.gov/pubmed/34273517
http://dx.doi.org/10.1016/j.ijid.2021.07.019
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author Pinto, Raquel Borges
Ramos, Ana Regina L.
Padua, Leidy Tovar
Swayze, Emma Jane
Cambou, Mary Catherine
Fiorini, Maristela
Melo, Marineide
Santos, Breno Riegel
Teixeira Canti, Ivete Cristina
Rieck Silveira, Mara Liane
Gonzalez Solari, Maria Inês
de Correa, Juliana Ferraz
Chew, Kara
dos Santos Varella, Ivana Rosângela
Nielsen-Saines, Karin
author_facet Pinto, Raquel Borges
Ramos, Ana Regina L.
Padua, Leidy Tovar
Swayze, Emma Jane
Cambou, Mary Catherine
Fiorini, Maristela
Melo, Marineide
Santos, Breno Riegel
Teixeira Canti, Ivete Cristina
Rieck Silveira, Mara Liane
Gonzalez Solari, Maria Inês
de Correa, Juliana Ferraz
Chew, Kara
dos Santos Varella, Ivana Rosângela
Nielsen-Saines, Karin
author_sort Pinto, Raquel Borges
collection PubMed
description OBJECTIVES: Porto Alegre, in south Brazil, has one of the highest Hepatitis C virus (HCV) infections rate in the country (84.4 cases/100,000 in 2018). Prenatal screening of HCV, however, has not been routinely offered. METHODS: We conducted a longitudinal study of pregnant women with HCV and their infants between January 2014 to December 2018. Screening for HCV antibodies was offered to all women delivering at our tertiary institution. HCV RT-PCR was performed if seropositive. Infants were followed prospectively. RESULTS: Among 18,953 pregnant women delivering, 17,810 were screened for HCV antibodies (93.9%) with 130 positive results. (HCV seroprevalence 0.7%). HCV RNA was detectable in 57/117 cases (48.7%). HCV viremia was associated with use of injectable drugs (p=0.03), inhaled/crack drug use (p=0.02), an HCV-seropositive partner, ≥3 lifetime sexual partners (p=<0.01). Genotype 1 was most prevalent (68%) during pregnancy. Among 43 children with follow-up, 6 (13%) were HCV infected (transmission rate 13.9%); genotype 3 infected 50%. Two infants (33%) cleared infection; mothers had genetic polymorphisms associated with clearance. CONCLUSION: HCV vertical transmission was high in our population, with HCV infection during pregnancy being vastly underdiagnosed. Public health efforts must focus on this vulnerable population for disease prevention and early treatment.
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spelling pubmed-84788362021-09-29 Prospective cohort study of children exposed to Hepatitis C virus through a pregnancy screening program Pinto, Raquel Borges Ramos, Ana Regina L. Padua, Leidy Tovar Swayze, Emma Jane Cambou, Mary Catherine Fiorini, Maristela Melo, Marineide Santos, Breno Riegel Teixeira Canti, Ivete Cristina Rieck Silveira, Mara Liane Gonzalez Solari, Maria Inês de Correa, Juliana Ferraz Chew, Kara dos Santos Varella, Ivana Rosângela Nielsen-Saines, Karin Int J Infect Dis Article OBJECTIVES: Porto Alegre, in south Brazil, has one of the highest Hepatitis C virus (HCV) infections rate in the country (84.4 cases/100,000 in 2018). Prenatal screening of HCV, however, has not been routinely offered. METHODS: We conducted a longitudinal study of pregnant women with HCV and their infants between January 2014 to December 2018. Screening for HCV antibodies was offered to all women delivering at our tertiary institution. HCV RT-PCR was performed if seropositive. Infants were followed prospectively. RESULTS: Among 18,953 pregnant women delivering, 17,810 were screened for HCV antibodies (93.9%) with 130 positive results. (HCV seroprevalence 0.7%). HCV RNA was detectable in 57/117 cases (48.7%). HCV viremia was associated with use of injectable drugs (p=0.03), inhaled/crack drug use (p=0.02), an HCV-seropositive partner, ≥3 lifetime sexual partners (p=<0.01). Genotype 1 was most prevalent (68%) during pregnancy. Among 43 children with follow-up, 6 (13%) were HCV infected (transmission rate 13.9%); genotype 3 infected 50%. Two infants (33%) cleared infection; mothers had genetic polymorphisms associated with clearance. CONCLUSION: HCV vertical transmission was high in our population, with HCV infection during pregnancy being vastly underdiagnosed. Public health efforts must focus on this vulnerable population for disease prevention and early treatment. 2021-07-14 2021-09 /pmc/articles/PMC8478836/ /pubmed/34273517 http://dx.doi.org/10.1016/j.ijid.2021.07.019 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Article
Pinto, Raquel Borges
Ramos, Ana Regina L.
Padua, Leidy Tovar
Swayze, Emma Jane
Cambou, Mary Catherine
Fiorini, Maristela
Melo, Marineide
Santos, Breno Riegel
Teixeira Canti, Ivete Cristina
Rieck Silveira, Mara Liane
Gonzalez Solari, Maria Inês
de Correa, Juliana Ferraz
Chew, Kara
dos Santos Varella, Ivana Rosângela
Nielsen-Saines, Karin
Prospective cohort study of children exposed to Hepatitis C virus through a pregnancy screening program
title Prospective cohort study of children exposed to Hepatitis C virus through a pregnancy screening program
title_full Prospective cohort study of children exposed to Hepatitis C virus through a pregnancy screening program
title_fullStr Prospective cohort study of children exposed to Hepatitis C virus through a pregnancy screening program
title_full_unstemmed Prospective cohort study of children exposed to Hepatitis C virus through a pregnancy screening program
title_short Prospective cohort study of children exposed to Hepatitis C virus through a pregnancy screening program
title_sort prospective cohort study of children exposed to hepatitis c virus through a pregnancy screening program
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478836/
https://www.ncbi.nlm.nih.gov/pubmed/34273517
http://dx.doi.org/10.1016/j.ijid.2021.07.019
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