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Inhibition of nuclear receptor RORα attenuates cartilage damage in osteoarthritis by modulating IL-6/STAT3 pathway

Osteoarthritis (OA) is characterized by cartilage destruction, chronic inflammation, and local pain. Evidence showed that retinoic acid receptor-related orphan receptor-α (RORα) is crucial in cartilage development and OA pathogenesis. Here, we investigated the role and molecular mechanism of RORα, a...

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Detalles Bibliográficos
Autores principales:	Liang, Tongzhou, Chen, Taiqiu, Qiu, Jincheng, Gao, Wenjie, Qiu, Xianjian, Zhu, Yuanxin, Wang, Xudong, Chen, Yanbo, Zhou, Hang, Deng, Zhihuai, Li, Pengfei, Xu, Caixia, Peng, Yan, Liang, Anjing, Su, Peiqiang, Gao, Bo, Huang, Dongsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478978/ https://www.ncbi.nlm.nih.gov/pubmed/34584074 http://dx.doi.org/10.1038/s41419-021-04170-0

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