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Analysis of a novel X-ray lens for converging beam radiotherapy
We describe the development and analysis of a new teletherapy modality that, through a novel approach to targeted radiation delivery, has the potential to provide greater conformality than conventional photon-based treatments. The proposed system uses an X-ray lens to reflect photons from a conventi...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478993/ https://www.ncbi.nlm.nih.gov/pubmed/34584192 http://dx.doi.org/10.1038/s41598-021-98888-8 |
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author | Bartkoski, Dirk A. Bar-David, Aharon Kleckner, Michael Mirkovic, Dragan Tailor, Ramesh Moradi-Kurdestany, Jamshid Borukhin, Shirly Harel, Ze’ev Burshtein, Zeev Zuck, Asaf Salehpour, Mohammad |
author_facet | Bartkoski, Dirk A. Bar-David, Aharon Kleckner, Michael Mirkovic, Dragan Tailor, Ramesh Moradi-Kurdestany, Jamshid Borukhin, Shirly Harel, Ze’ev Burshtein, Zeev Zuck, Asaf Salehpour, Mohammad |
author_sort | Bartkoski, Dirk A. |
collection | PubMed |
description | We describe the development and analysis of a new teletherapy modality that, through a novel approach to targeted radiation delivery, has the potential to provide greater conformality than conventional photon-based treatments. The proposed system uses an X-ray lens to reflect photons from a conventional X-ray tube toward a focal spot. The resulting dose distributions have a highly localized peak dose, with lower doses in the converging radiation cone. Physical principles governing the design of this system are presented, along with a series of measurements analyzing various characteristics of the converging beam. The beam was designed to be nearly monoenergetic (~ 59 keV), with an energy bandwidth of approximately 10 keV allowing for treatment energies lower than conventional therapies. The focal spot was measured to be approximately 2.5 cm long and 4 mm wide. Mounting the proposed X-ray delivery system on a robotic arm would allow sub-millimeter accuracy in focal spot positioning, resulting in highly conformal dose distribution via the optimal placement of individual focal spots within the target volume. Aspects of this novel radiation beam are discussed considering their possible clinical application as a treatment approach that takes maximum advantage of the unique properties afforded by converging X-ray beam therapy. |
format | Online Article Text |
id | pubmed-8478993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-84789932021-09-30 Analysis of a novel X-ray lens for converging beam radiotherapy Bartkoski, Dirk A. Bar-David, Aharon Kleckner, Michael Mirkovic, Dragan Tailor, Ramesh Moradi-Kurdestany, Jamshid Borukhin, Shirly Harel, Ze’ev Burshtein, Zeev Zuck, Asaf Salehpour, Mohammad Sci Rep Article We describe the development and analysis of a new teletherapy modality that, through a novel approach to targeted radiation delivery, has the potential to provide greater conformality than conventional photon-based treatments. The proposed system uses an X-ray lens to reflect photons from a conventional X-ray tube toward a focal spot. The resulting dose distributions have a highly localized peak dose, with lower doses in the converging radiation cone. Physical principles governing the design of this system are presented, along with a series of measurements analyzing various characteristics of the converging beam. The beam was designed to be nearly monoenergetic (~ 59 keV), with an energy bandwidth of approximately 10 keV allowing for treatment energies lower than conventional therapies. The focal spot was measured to be approximately 2.5 cm long and 4 mm wide. Mounting the proposed X-ray delivery system on a robotic arm would allow sub-millimeter accuracy in focal spot positioning, resulting in highly conformal dose distribution via the optimal placement of individual focal spots within the target volume. Aspects of this novel radiation beam are discussed considering their possible clinical application as a treatment approach that takes maximum advantage of the unique properties afforded by converging X-ray beam therapy. Nature Publishing Group UK 2021-09-28 /pmc/articles/PMC8478993/ /pubmed/34584192 http://dx.doi.org/10.1038/s41598-021-98888-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Bartkoski, Dirk A. Bar-David, Aharon Kleckner, Michael Mirkovic, Dragan Tailor, Ramesh Moradi-Kurdestany, Jamshid Borukhin, Shirly Harel, Ze’ev Burshtein, Zeev Zuck, Asaf Salehpour, Mohammad Analysis of a novel X-ray lens for converging beam radiotherapy |
title | Analysis of a novel X-ray lens for converging beam radiotherapy |
title_full | Analysis of a novel X-ray lens for converging beam radiotherapy |
title_fullStr | Analysis of a novel X-ray lens for converging beam radiotherapy |
title_full_unstemmed | Analysis of a novel X-ray lens for converging beam radiotherapy |
title_short | Analysis of a novel X-ray lens for converging beam radiotherapy |
title_sort | analysis of a novel x-ray lens for converging beam radiotherapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478993/ https://www.ncbi.nlm.nih.gov/pubmed/34584192 http://dx.doi.org/10.1038/s41598-021-98888-8 |
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