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Analysis of a novel X-ray lens for converging beam radiotherapy

We describe the development and analysis of a new teletherapy modality that, through a novel approach to targeted radiation delivery, has the potential to provide greater conformality than conventional photon-based treatments. The proposed system uses an X-ray lens to reflect photons from a conventi...

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Autores principales: Bartkoski, Dirk A., Bar-David, Aharon, Kleckner, Michael, Mirkovic, Dragan, Tailor, Ramesh, Moradi-Kurdestany, Jamshid, Borukhin, Shirly, Harel, Ze’ev, Burshtein, Zeev, Zuck, Asaf, Salehpour, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478993/
https://www.ncbi.nlm.nih.gov/pubmed/34584192
http://dx.doi.org/10.1038/s41598-021-98888-8
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author Bartkoski, Dirk A.
Bar-David, Aharon
Kleckner, Michael
Mirkovic, Dragan
Tailor, Ramesh
Moradi-Kurdestany, Jamshid
Borukhin, Shirly
Harel, Ze’ev
Burshtein, Zeev
Zuck, Asaf
Salehpour, Mohammad
author_facet Bartkoski, Dirk A.
Bar-David, Aharon
Kleckner, Michael
Mirkovic, Dragan
Tailor, Ramesh
Moradi-Kurdestany, Jamshid
Borukhin, Shirly
Harel, Ze’ev
Burshtein, Zeev
Zuck, Asaf
Salehpour, Mohammad
author_sort Bartkoski, Dirk A.
collection PubMed
description We describe the development and analysis of a new teletherapy modality that, through a novel approach to targeted radiation delivery, has the potential to provide greater conformality than conventional photon-based treatments. The proposed system uses an X-ray lens to reflect photons from a conventional X-ray tube toward a focal spot. The resulting dose distributions have a highly localized peak dose, with lower doses in the converging radiation cone. Physical principles governing the design of this system are presented, along with a series of measurements analyzing various characteristics of the converging beam. The beam was designed to be nearly monoenergetic (~ 59 keV), with an energy bandwidth of approximately 10 keV allowing for treatment energies lower than conventional therapies. The focal spot was measured to be approximately 2.5 cm long and 4 mm wide. Mounting the proposed X-ray delivery system on a robotic arm would allow sub-millimeter accuracy in focal spot positioning, resulting in highly conformal dose distribution via the optimal placement of individual focal spots within the target volume. Aspects of this novel radiation beam are discussed considering their possible clinical application as a treatment approach that takes maximum advantage of the unique properties afforded by converging X-ray beam therapy.
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spelling pubmed-84789932021-09-30 Analysis of a novel X-ray lens for converging beam radiotherapy Bartkoski, Dirk A. Bar-David, Aharon Kleckner, Michael Mirkovic, Dragan Tailor, Ramesh Moradi-Kurdestany, Jamshid Borukhin, Shirly Harel, Ze’ev Burshtein, Zeev Zuck, Asaf Salehpour, Mohammad Sci Rep Article We describe the development and analysis of a new teletherapy modality that, through a novel approach to targeted radiation delivery, has the potential to provide greater conformality than conventional photon-based treatments. The proposed system uses an X-ray lens to reflect photons from a conventional X-ray tube toward a focal spot. The resulting dose distributions have a highly localized peak dose, with lower doses in the converging radiation cone. Physical principles governing the design of this system are presented, along with a series of measurements analyzing various characteristics of the converging beam. The beam was designed to be nearly monoenergetic (~ 59 keV), with an energy bandwidth of approximately 10 keV allowing for treatment energies lower than conventional therapies. The focal spot was measured to be approximately 2.5 cm long and 4 mm wide. Mounting the proposed X-ray delivery system on a robotic arm would allow sub-millimeter accuracy in focal spot positioning, resulting in highly conformal dose distribution via the optimal placement of individual focal spots within the target volume. Aspects of this novel radiation beam are discussed considering their possible clinical application as a treatment approach that takes maximum advantage of the unique properties afforded by converging X-ray beam therapy. Nature Publishing Group UK 2021-09-28 /pmc/articles/PMC8478993/ /pubmed/34584192 http://dx.doi.org/10.1038/s41598-021-98888-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Bartkoski, Dirk A.
Bar-David, Aharon
Kleckner, Michael
Mirkovic, Dragan
Tailor, Ramesh
Moradi-Kurdestany, Jamshid
Borukhin, Shirly
Harel, Ze’ev
Burshtein, Zeev
Zuck, Asaf
Salehpour, Mohammad
Analysis of a novel X-ray lens for converging beam radiotherapy
title Analysis of a novel X-ray lens for converging beam radiotherapy
title_full Analysis of a novel X-ray lens for converging beam radiotherapy
title_fullStr Analysis of a novel X-ray lens for converging beam radiotherapy
title_full_unstemmed Analysis of a novel X-ray lens for converging beam radiotherapy
title_short Analysis of a novel X-ray lens for converging beam radiotherapy
title_sort analysis of a novel x-ray lens for converging beam radiotherapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478993/
https://www.ncbi.nlm.nih.gov/pubmed/34584192
http://dx.doi.org/10.1038/s41598-021-98888-8
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