Identical twins carry a persistent epigenetic signature of early genome programming

Monozygotic (MZ) twins and higher-order multiples arise when a zygote splits during pre-implantation stages of development. The mechanisms underpinning this event have remained a mystery. Because MZ twinning rarely runs in families, the leading hypothesis is that it occurs at random. Here, we show t...

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Autores principales: van Dongen, Jenny, Gordon, Scott D., McRae, Allan F., Odintsova, Veronika V., Mbarek, Hamdi, Breeze, Charles E., Sugden, Karen, Lundgren, Sara, Castillo-Fernandez, Juan E., Hannon, Eilis, Moffitt, Terrie E., Hagenbeek, Fiona A., van Beijsterveldt, Catharina E. M., Jan Hottenga, Jouke, Tsai, Pei-Chien, Min, Josine L., Hemani, Gibran, Ehli, Erik A., Paul, Franziska, Stern, Claudio D., Heijmans, Bastiaan T., Slagboom, P. Eline, Daxinger, Lucia, van der Maarel, Silvère M., de Geus, Eco J. C., Willemsen, Gonneke, Montgomery, Grant W., Reversade, Bruno, Ollikainen, Miina, Kaprio, Jaakko, Spector, Tim D., Bell, Jordana T., Mill, Jonathan, Caspi, Avshalom, Martin, Nicholas G., Boomsma, Dorret I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479069/
https://www.ncbi.nlm.nih.gov/pubmed/34584077
http://dx.doi.org/10.1038/s41467-021-25583-7
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author van Dongen, Jenny
Gordon, Scott D.
McRae, Allan F.
Odintsova, Veronika V.
Mbarek, Hamdi
Breeze, Charles E.
Sugden, Karen
Lundgren, Sara
Castillo-Fernandez, Juan E.
Hannon, Eilis
Moffitt, Terrie E.
Hagenbeek, Fiona A.
van Beijsterveldt, Catharina E. M.
Jan Hottenga, Jouke
Tsai, Pei-Chien
Min, Josine L.
Hemani, Gibran
Ehli, Erik A.
Paul, Franziska
Stern, Claudio D.
Heijmans, Bastiaan T.
Slagboom, P. Eline
Daxinger, Lucia
van der Maarel, Silvère M.
de Geus, Eco J. C.
Willemsen, Gonneke
Montgomery, Grant W.
Reversade, Bruno
Ollikainen, Miina
Kaprio, Jaakko
Spector, Tim D.
Bell, Jordana T.
Mill, Jonathan
Caspi, Avshalom
Martin, Nicholas G.
Boomsma, Dorret I.
author_facet van Dongen, Jenny
Gordon, Scott D.
McRae, Allan F.
Odintsova, Veronika V.
Mbarek, Hamdi
Breeze, Charles E.
Sugden, Karen
Lundgren, Sara
Castillo-Fernandez, Juan E.
Hannon, Eilis
Moffitt, Terrie E.
Hagenbeek, Fiona A.
van Beijsterveldt, Catharina E. M.
Jan Hottenga, Jouke
Tsai, Pei-Chien
Min, Josine L.
Hemani, Gibran
Ehli, Erik A.
Paul, Franziska
Stern, Claudio D.
Heijmans, Bastiaan T.
Slagboom, P. Eline
Daxinger, Lucia
van der Maarel, Silvère M.
de Geus, Eco J. C.
Willemsen, Gonneke
Montgomery, Grant W.
Reversade, Bruno
Ollikainen, Miina
Kaprio, Jaakko
Spector, Tim D.
Bell, Jordana T.
Mill, Jonathan
Caspi, Avshalom
Martin, Nicholas G.
Boomsma, Dorret I.
author_sort van Dongen, Jenny
collection PubMed
description Monozygotic (MZ) twins and higher-order multiples arise when a zygote splits during pre-implantation stages of development. The mechanisms underpinning this event have remained a mystery. Because MZ twinning rarely runs in families, the leading hypothesis is that it occurs at random. Here, we show that MZ twinning is strongly associated with a stable DNA methylation signature in adult somatic tissues. This signature spans regions near telomeres and centromeres, Polycomb-repressed regions and heterochromatin, genes involved in cell-adhesion, WNT signaling, cell fate, and putative human metastable epialleles. Our study also demonstrates a never-anticipated corollary: because identical twins keep a lifelong molecular signature, we can retrospectively diagnose if a person was conceived as monozygotic twin.
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spelling pubmed-84790692021-10-22 Identical twins carry a persistent epigenetic signature of early genome programming van Dongen, Jenny Gordon, Scott D. McRae, Allan F. Odintsova, Veronika V. Mbarek, Hamdi Breeze, Charles E. Sugden, Karen Lundgren, Sara Castillo-Fernandez, Juan E. Hannon, Eilis Moffitt, Terrie E. Hagenbeek, Fiona A. van Beijsterveldt, Catharina E. M. Jan Hottenga, Jouke Tsai, Pei-Chien Min, Josine L. Hemani, Gibran Ehli, Erik A. Paul, Franziska Stern, Claudio D. Heijmans, Bastiaan T. Slagboom, P. Eline Daxinger, Lucia van der Maarel, Silvère M. de Geus, Eco J. C. Willemsen, Gonneke Montgomery, Grant W. Reversade, Bruno Ollikainen, Miina Kaprio, Jaakko Spector, Tim D. Bell, Jordana T. Mill, Jonathan Caspi, Avshalom Martin, Nicholas G. Boomsma, Dorret I. Nat Commun Article Monozygotic (MZ) twins and higher-order multiples arise when a zygote splits during pre-implantation stages of development. The mechanisms underpinning this event have remained a mystery. Because MZ twinning rarely runs in families, the leading hypothesis is that it occurs at random. Here, we show that MZ twinning is strongly associated with a stable DNA methylation signature in adult somatic tissues. This signature spans regions near telomeres and centromeres, Polycomb-repressed regions and heterochromatin, genes involved in cell-adhesion, WNT signaling, cell fate, and putative human metastable epialleles. Our study also demonstrates a never-anticipated corollary: because identical twins keep a lifelong molecular signature, we can retrospectively diagnose if a person was conceived as monozygotic twin. Nature Publishing Group UK 2021-09-28 /pmc/articles/PMC8479069/ /pubmed/34584077 http://dx.doi.org/10.1038/s41467-021-25583-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
van Dongen, Jenny
Gordon, Scott D.
McRae, Allan F.
Odintsova, Veronika V.
Mbarek, Hamdi
Breeze, Charles E.
Sugden, Karen
Lundgren, Sara
Castillo-Fernandez, Juan E.
Hannon, Eilis
Moffitt, Terrie E.
Hagenbeek, Fiona A.
van Beijsterveldt, Catharina E. M.
Jan Hottenga, Jouke
Tsai, Pei-Chien
Min, Josine L.
Hemani, Gibran
Ehli, Erik A.
Paul, Franziska
Stern, Claudio D.
Heijmans, Bastiaan T.
Slagboom, P. Eline
Daxinger, Lucia
van der Maarel, Silvère M.
de Geus, Eco J. C.
Willemsen, Gonneke
Montgomery, Grant W.
Reversade, Bruno
Ollikainen, Miina
Kaprio, Jaakko
Spector, Tim D.
Bell, Jordana T.
Mill, Jonathan
Caspi, Avshalom
Martin, Nicholas G.
Boomsma, Dorret I.
Identical twins carry a persistent epigenetic signature of early genome programming
title Identical twins carry a persistent epigenetic signature of early genome programming
title_full Identical twins carry a persistent epigenetic signature of early genome programming
title_fullStr Identical twins carry a persistent epigenetic signature of early genome programming
title_full_unstemmed Identical twins carry a persistent epigenetic signature of early genome programming
title_short Identical twins carry a persistent epigenetic signature of early genome programming
title_sort identical twins carry a persistent epigenetic signature of early genome programming
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479069/
https://www.ncbi.nlm.nih.gov/pubmed/34584077
http://dx.doi.org/10.1038/s41467-021-25583-7
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