Spontaneous and Naloxone-Precipitated Withdrawal Behaviors From Chronic Opiates are Accompanied by Changes in N-Oleoylglycine and N-Oleoylalanine Levels in the Brain and Ameliorated by Treatment With These Mediators

Rationale: The endocannabinoidome mediators, N-Oleoylglycine (OlGly) and N-Oleoylalanine (OlAla), have been shown to reduce acute naloxone-precipitated morphine withdrawal affective and somatic responses. Objectives: To determine the role and mechanism of action of OlGly and OlAla in withdrawal resp...

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Detalles Bibliográficos
Autores principales: Ayoub, Samantha M., Piscitelli, Fabiana, Silvestri, Cristoforo, Limebeer, Cheryl L., Rock, Erin M., Smoum, Reem, Farag, Mathew, de Almeida, Hannah, Sullivan, Megan T., Lacroix, Sébastien, Boubertakh, Besma, Nallabelli, Nayudu, Lichtman, Aron H, Leri, Francesco, Mechoulam, Raphael, Di Marzo, Vincenzo, Parker, Linda A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479102/
https://www.ncbi.nlm.nih.gov/pubmed/34603019
http://dx.doi.org/10.3389/fphar.2021.706703

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