CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression of coherent circadian rhythm but not in generation of circadian oscillation in the neonatal mouse SCN

Clock genes Cry1 and Cry2, inhibitory components of core molecular feedback loop, are regarded as critical molecules for the circadian rhythm generation in mammals. A double knockout of Cry1 and Cry2 abolishes the circadian behavioral rhythm in adult mice under constant darkness. However, robust cir...

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Detalles Bibliográficos
Autores principales: Ono, Daisuke, Honma, Ken-ichi, Schmal, Christoph, Takumi, Toru, Kawamoto, Takeshi, Fujimoto, Katsumi, Kato, Yukio, Honma, Sato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479135/
https://www.ncbi.nlm.nih.gov/pubmed/34584158
http://dx.doi.org/10.1038/s41598-021-98532-5

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