Cargando…
The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium
Adipose tissue (AT) biology is linked to cardiovascular health since obesity is associated with cardiovascular disease (CVD) and positively correlated with excessive visceral fat accumulation. AT signaling to myocardial cells through soluble factors known as adipokines, cardiokines, branched-chain a...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479191/ https://www.ncbi.nlm.nih.gov/pubmed/34603210 http://dx.doi.org/10.3389/fendo.2021.735070 |
_version_ | 1784576198249021440 |
---|---|
author | Bermúdez, Valmore Durán, Pablo Rojas, Edward Díaz, María P. Rivas, José Nava, Manuel Chacín, Maricarmen Cabrera de Bravo, Mayela Carrasquero, Rubén Ponce, Clímaco Cano Górriz, José Luis D´Marco, Luis |
author_facet | Bermúdez, Valmore Durán, Pablo Rojas, Edward Díaz, María P. Rivas, José Nava, Manuel Chacín, Maricarmen Cabrera de Bravo, Mayela Carrasquero, Rubén Ponce, Clímaco Cano Górriz, José Luis D´Marco, Luis |
author_sort | Bermúdez, Valmore |
collection | PubMed |
description | Adipose tissue (AT) biology is linked to cardiovascular health since obesity is associated with cardiovascular disease (CVD) and positively correlated with excessive visceral fat accumulation. AT signaling to myocardial cells through soluble factors known as adipokines, cardiokines, branched-chain amino acids and small molecules like microRNAs, undoubtedly influence myocardial cells and AT function via the endocrine-paracrine mechanisms of action. Unfortunately, abnormal total and visceral adiposity can alter this harmonious signaling network, resulting in tissue hypoxia and monocyte/macrophage adipose infiltration occurring alongside expanded intra-abdominal and epicardial fat depots seen in the human obese phenotype. These processes promote an abnormal adipocyte proteomic reprogramming, whereby these cells become a source of abnormal signals, affecting vascular and myocardial tissues, leading to meta-inflammation, atrial fibrillation, coronary artery disease, heart hypertrophy, heart failure and myocardial infarction. This review first discusses the pathophysiology and consequences of adipose tissue expansion, particularly their association with meta-inflammation and microbiota dysbiosis. We also explore the precise mechanisms involved in metabolic reprogramming in AT that represent plausible causative factors for CVD. Finally, we clarify how lifestyle changes could promote improvement in myocardiocyte function in the context of changes in AT proteomics and a better gut microbiome profile to develop effective, non-pharmacologic approaches to CVD. |
format | Online Article Text |
id | pubmed-8479191 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84791912021-09-30 The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium Bermúdez, Valmore Durán, Pablo Rojas, Edward Díaz, María P. Rivas, José Nava, Manuel Chacín, Maricarmen Cabrera de Bravo, Mayela Carrasquero, Rubén Ponce, Clímaco Cano Górriz, José Luis D´Marco, Luis Front Endocrinol (Lausanne) Endocrinology Adipose tissue (AT) biology is linked to cardiovascular health since obesity is associated with cardiovascular disease (CVD) and positively correlated with excessive visceral fat accumulation. AT signaling to myocardial cells through soluble factors known as adipokines, cardiokines, branched-chain amino acids and small molecules like microRNAs, undoubtedly influence myocardial cells and AT function via the endocrine-paracrine mechanisms of action. Unfortunately, abnormal total and visceral adiposity can alter this harmonious signaling network, resulting in tissue hypoxia and monocyte/macrophage adipose infiltration occurring alongside expanded intra-abdominal and epicardial fat depots seen in the human obese phenotype. These processes promote an abnormal adipocyte proteomic reprogramming, whereby these cells become a source of abnormal signals, affecting vascular and myocardial tissues, leading to meta-inflammation, atrial fibrillation, coronary artery disease, heart hypertrophy, heart failure and myocardial infarction. This review first discusses the pathophysiology and consequences of adipose tissue expansion, particularly their association with meta-inflammation and microbiota dysbiosis. We also explore the precise mechanisms involved in metabolic reprogramming in AT that represent plausible causative factors for CVD. Finally, we clarify how lifestyle changes could promote improvement in myocardiocyte function in the context of changes in AT proteomics and a better gut microbiome profile to develop effective, non-pharmacologic approaches to CVD. Frontiers Media S.A. 2021-09-15 /pmc/articles/PMC8479191/ /pubmed/34603210 http://dx.doi.org/10.3389/fendo.2021.735070 Text en Copyright © 2021 Bermúdez, Durán, Rojas, Díaz, Rivas, Nava, Chacín, Cabrera de Bravo, Carrasquero, Ponce, Górriz and D´Marco https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Bermúdez, Valmore Durán, Pablo Rojas, Edward Díaz, María P. Rivas, José Nava, Manuel Chacín, Maricarmen Cabrera de Bravo, Mayela Carrasquero, Rubén Ponce, Clímaco Cano Górriz, José Luis D´Marco, Luis The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium |
title | The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium |
title_full | The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium |
title_fullStr | The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium |
title_full_unstemmed | The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium |
title_short | The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium |
title_sort | sick adipose tissue: new insights into defective signaling and crosstalk with the myocardium |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479191/ https://www.ncbi.nlm.nih.gov/pubmed/34603210 http://dx.doi.org/10.3389/fendo.2021.735070 |
work_keys_str_mv | AT bermudezvalmore thesickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT duranpablo thesickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT rojasedward thesickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT diazmariap thesickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT rivasjose thesickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT navamanuel thesickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT chacinmaricarmen thesickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT cabreradebravomayela thesickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT carrasqueroruben thesickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT ponceclimacocano thesickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT gorrizjoseluis thesickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT dmarcoluis thesickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT bermudezvalmore sickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT duranpablo sickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT rojasedward sickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT diazmariap sickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT rivasjose sickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT navamanuel sickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT chacinmaricarmen sickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT cabreradebravomayela sickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT carrasqueroruben sickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT ponceclimacocano sickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT gorrizjoseluis sickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium AT dmarcoluis sickadiposetissuenewinsightsintodefectivesignalingandcrosstalkwiththemyocardium |