Marginal Zone Lymphoma and Lung Adenocarcinoma with an EGFR Exon 19 E746-S752del Mutation in a Patient with IgG4-related Disease

A 68-year-old man presented with a solid mass at the left renal pelvis and ureter with multiple systemic lymphadenopathies and a mass with a cavity in the right lower lobe of the lung. While a transbronchial lung biopsy revealed no malignancy, a biopsy of the renal pelvis showed marginal zone lympho...

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Autores principales: Okawa, Sachi, Rai, Kammei, Fujii, Nobuharu, Gion, Yuka, Ninomiya, Kiichiro, Kato, Yuka, Taniguchi, Akihiko, Kubo, Toshio, Ichihara, Eiki, Ohashi, Kadoaki, Miyahara, Nobuaki, Hotta, Katsuyuki, Tabata, Masahiro, Maeda, Yoshinobu, Kiura, Katsuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479213/
https://www.ncbi.nlm.nih.gov/pubmed/33775999
http://dx.doi.org/10.2169/internalmedicine.6470-20
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author Okawa, Sachi
Rai, Kammei
Fujii, Nobuharu
Gion, Yuka
Ninomiya, Kiichiro
Kato, Yuka
Taniguchi, Akihiko
Kubo, Toshio
Ichihara, Eiki
Ohashi, Kadoaki
Miyahara, Nobuaki
Hotta, Katsuyuki
Tabata, Masahiro
Maeda, Yoshinobu
Kiura, Katsuyuki
author_facet Okawa, Sachi
Rai, Kammei
Fujii, Nobuharu
Gion, Yuka
Ninomiya, Kiichiro
Kato, Yuka
Taniguchi, Akihiko
Kubo, Toshio
Ichihara, Eiki
Ohashi, Kadoaki
Miyahara, Nobuaki
Hotta, Katsuyuki
Tabata, Masahiro
Maeda, Yoshinobu
Kiura, Katsuyuki
author_sort Okawa, Sachi
collection PubMed
description A 68-year-old man presented with a solid mass at the left renal pelvis and ureter with multiple systemic lymphadenopathies and a mass with a cavity in the right lower lobe of the lung. While a transbronchial lung biopsy revealed no malignancy, a biopsy of the renal pelvis showed marginal zone lymphoma with polyclonal IgG4-positive cells. The serum IgG4 level and presence of a bilateral orbital mass suggested Mikulicz disease. The lesions shrank following the administration of steroids. A rebiopsy confirmed lung adenocarcinoma, and its background showed IgG4-positive cells a year later. IgG4-related diseases require careful follow-up because they can be complicated by malignancy.
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spelling pubmed-84792132021-10-08 Marginal Zone Lymphoma and Lung Adenocarcinoma with an EGFR Exon 19 E746-S752del Mutation in a Patient with IgG4-related Disease Okawa, Sachi Rai, Kammei Fujii, Nobuharu Gion, Yuka Ninomiya, Kiichiro Kato, Yuka Taniguchi, Akihiko Kubo, Toshio Ichihara, Eiki Ohashi, Kadoaki Miyahara, Nobuaki Hotta, Katsuyuki Tabata, Masahiro Maeda, Yoshinobu Kiura, Katsuyuki Intern Med Case Report A 68-year-old man presented with a solid mass at the left renal pelvis and ureter with multiple systemic lymphadenopathies and a mass with a cavity in the right lower lobe of the lung. While a transbronchial lung biopsy revealed no malignancy, a biopsy of the renal pelvis showed marginal zone lymphoma with polyclonal IgG4-positive cells. The serum IgG4 level and presence of a bilateral orbital mass suggested Mikulicz disease. The lesions shrank following the administration of steroids. A rebiopsy confirmed lung adenocarcinoma, and its background showed IgG4-positive cells a year later. IgG4-related diseases require careful follow-up because they can be complicated by malignancy. The Japanese Society of Internal Medicine 2021-03-29 2021-09-01 /pmc/articles/PMC8479213/ /pubmed/33775999 http://dx.doi.org/10.2169/internalmedicine.6470-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Okawa, Sachi
Rai, Kammei
Fujii, Nobuharu
Gion, Yuka
Ninomiya, Kiichiro
Kato, Yuka
Taniguchi, Akihiko
Kubo, Toshio
Ichihara, Eiki
Ohashi, Kadoaki
Miyahara, Nobuaki
Hotta, Katsuyuki
Tabata, Masahiro
Maeda, Yoshinobu
Kiura, Katsuyuki
Marginal Zone Lymphoma and Lung Adenocarcinoma with an EGFR Exon 19 E746-S752del Mutation in a Patient with IgG4-related Disease
title Marginal Zone Lymphoma and Lung Adenocarcinoma with an EGFR Exon 19 E746-S752del Mutation in a Patient with IgG4-related Disease
title_full Marginal Zone Lymphoma and Lung Adenocarcinoma with an EGFR Exon 19 E746-S752del Mutation in a Patient with IgG4-related Disease
title_fullStr Marginal Zone Lymphoma and Lung Adenocarcinoma with an EGFR Exon 19 E746-S752del Mutation in a Patient with IgG4-related Disease
title_full_unstemmed Marginal Zone Lymphoma and Lung Adenocarcinoma with an EGFR Exon 19 E746-S752del Mutation in a Patient with IgG4-related Disease
title_short Marginal Zone Lymphoma and Lung Adenocarcinoma with an EGFR Exon 19 E746-S752del Mutation in a Patient with IgG4-related Disease
title_sort marginal zone lymphoma and lung adenocarcinoma with an egfr exon 19 e746-s752del mutation in a patient with igg4-related disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479213/
https://www.ncbi.nlm.nih.gov/pubmed/33775999
http://dx.doi.org/10.2169/internalmedicine.6470-20
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