A Rare Case of Pulmonary Tumor Thrombotic Microangiopathy Associated with Micropapillary Urothelial Carcinoma of the Urinary Bladder: An Autopsy Case

A 70-year-old woman was hospitalized with dyspnea. A transthoracic echocardiogram indicated an elevated systolic pulmonary artery pressure, and the cytology specimens obtained using a pulmonary artery catheter confirmed adenocarcinoma metastasis. Diffusion-weighted whole-body imaging with background...

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Autores principales: Kitazono, Takafumi, Tsubouchi, Kazuya, Ibusuki, Ritsu, Inoue, Katsuhiro, Miyajima, Kimitaka, Motoshita, Junichi, Okamatsu, Yuki, Harada, Taishi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479233/
https://www.ncbi.nlm.nih.gov/pubmed/33716284
http://dx.doi.org/10.2169/internalmedicine.6553-20
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author Kitazono, Takafumi
Tsubouchi, Kazuya
Ibusuki, Ritsu
Inoue, Katsuhiro
Miyajima, Kimitaka
Motoshita, Junichi
Okamatsu, Yuki
Harada, Taishi
author_facet Kitazono, Takafumi
Tsubouchi, Kazuya
Ibusuki, Ritsu
Inoue, Katsuhiro
Miyajima, Kimitaka
Motoshita, Junichi
Okamatsu, Yuki
Harada, Taishi
author_sort Kitazono, Takafumi
collection PubMed
description A 70-year-old woman was hospitalized with dyspnea. A transthoracic echocardiogram indicated an elevated systolic pulmonary artery pressure, and the cytology specimens obtained using a pulmonary artery catheter confirmed adenocarcinoma metastasis. Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) detected high-signal-intensity lesions in the urinary bladder. The patient died of respiratory failure and a postmortem examination was performed. Tumor cells in the bladder were immunohistochemically positive for GATA3, indicating micropapillary urothelial carcinoma, which is a rare variant of urothelial carcinoma and considered an adenocarcinoma subtype. This case is the first autopsy case of pulmonary tumor thrombotic microangiopathy (PTTM) associated with micropapillary urothelial carcinoma of the urinary bladder.
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spelling pubmed-84792332021-10-08 A Rare Case of Pulmonary Tumor Thrombotic Microangiopathy Associated with Micropapillary Urothelial Carcinoma of the Urinary Bladder: An Autopsy Case Kitazono, Takafumi Tsubouchi, Kazuya Ibusuki, Ritsu Inoue, Katsuhiro Miyajima, Kimitaka Motoshita, Junichi Okamatsu, Yuki Harada, Taishi Intern Med Case Report A 70-year-old woman was hospitalized with dyspnea. A transthoracic echocardiogram indicated an elevated systolic pulmonary artery pressure, and the cytology specimens obtained using a pulmonary artery catheter confirmed adenocarcinoma metastasis. Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) detected high-signal-intensity lesions in the urinary bladder. The patient died of respiratory failure and a postmortem examination was performed. Tumor cells in the bladder were immunohistochemically positive for GATA3, indicating micropapillary urothelial carcinoma, which is a rare variant of urothelial carcinoma and considered an adenocarcinoma subtype. This case is the first autopsy case of pulmonary tumor thrombotic microangiopathy (PTTM) associated with micropapillary urothelial carcinoma of the urinary bladder. The Japanese Society of Internal Medicine 2021-03-15 2021-09-01 /pmc/articles/PMC8479233/ /pubmed/33716284 http://dx.doi.org/10.2169/internalmedicine.6553-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kitazono, Takafumi
Tsubouchi, Kazuya
Ibusuki, Ritsu
Inoue, Katsuhiro
Miyajima, Kimitaka
Motoshita, Junichi
Okamatsu, Yuki
Harada, Taishi
A Rare Case of Pulmonary Tumor Thrombotic Microangiopathy Associated with Micropapillary Urothelial Carcinoma of the Urinary Bladder: An Autopsy Case
title A Rare Case of Pulmonary Tumor Thrombotic Microangiopathy Associated with Micropapillary Urothelial Carcinoma of the Urinary Bladder: An Autopsy Case
title_full A Rare Case of Pulmonary Tumor Thrombotic Microangiopathy Associated with Micropapillary Urothelial Carcinoma of the Urinary Bladder: An Autopsy Case
title_fullStr A Rare Case of Pulmonary Tumor Thrombotic Microangiopathy Associated with Micropapillary Urothelial Carcinoma of the Urinary Bladder: An Autopsy Case
title_full_unstemmed A Rare Case of Pulmonary Tumor Thrombotic Microangiopathy Associated with Micropapillary Urothelial Carcinoma of the Urinary Bladder: An Autopsy Case
title_short A Rare Case of Pulmonary Tumor Thrombotic Microangiopathy Associated with Micropapillary Urothelial Carcinoma of the Urinary Bladder: An Autopsy Case
title_sort rare case of pulmonary tumor thrombotic microangiopathy associated with micropapillary urothelial carcinoma of the urinary bladder: an autopsy case
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479233/
https://www.ncbi.nlm.nih.gov/pubmed/33716284
http://dx.doi.org/10.2169/internalmedicine.6553-20
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