Cargando…

Advances in mRNA 5-methylcytosine modifications: Detection, effectors, biological functions, and clinical relevance

5-methylcytosine (m(5)C) post-transcriptional modifications affect the maturation, stability, and translation of the mRNA molecule. These modifications play an important role in many physiological and pathological processes, including stress response, tumorigenesis, tumor cell migration, embryogenes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Gangqiang, Pan, Kan, Fang, Su, Ye, Lele, Tong, Xinya, Wang, Zhibin, Xue, Xiangyang, Zhang, Huidi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479277/ https://www.ncbi.nlm.nih.gov/pubmed/34631286 http://dx.doi.org/10.1016/j.omtn.2021.08.020

Ejemplares similares

Disease Activity-Associated Alteration of mRNA m(5) C Methylation in CD4(+) T Cells of Systemic Lupus Erythematosus
por: Guo, Gangqiang, et al.
Publicado: (2020)

5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes
por: Liu, Meng, et al.
Publicado: (2022)

Epitranscriptomic N4-Acetylcytidine Profiling in CD4(+) T Cells of Systemic Lupus Erythematosus
por: Guo, Gangqiang, et al.
Publicado: (2020)

Transcriptional Landscape of Enhancer RNAs in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus
por: Guo, Gangqiang, et al.
Publicado: (2022)

Four Types of RNA Modification Writer-Related lncRNAs Are Effective Predictors of Prognosis and Immunotherapy Response in Serous Ovarian Carcinoma
por: Ye, Lele, et al.
Publicado: (2022)

Multiple links between 5-methylcytosine content of mRNA and translation
por: Schumann, Ulrike, et al.
Publicado: (2020)

Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition
por: Zhang, Yuan, et al.
Publicado: (2017)

Alteration of mRNA 5-Methylcytosine Modification in Neurons After OGD/R and Potential Roles in Cell Stress Response and Apoptosis
por: Jian, Huan, et al.
Publicado: (2021)

YAP 5-methylcytosine modification increases its mRNA stability and promotes the transcription of exosome secretion-related genes in lung adenocarcinoma
por: Yu, Wenjun, et al.
Publicado: (2022)

5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m(5)C reader
por: Yang, Xin, et al.
Publicado: (2017)

Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond
por: Breiling, Achim, et al.
Publicado: (2015)

Role of main RNA modifications in cancer: N(6)-methyladenosine, 5-methylcytosine, and pseudouridine
por: Xue, Chen, et al.
Publicado: (2022)

NovelmiRNA-25 inhibits AMPD2 in peripheral blood mononuclear cells of patients with systemic lupus erythematosus and represents a promising novel biomarker
por: Guo, Gangqiang, et al.
Publicado: (2018)

Hsa_circ_0000479 as a Novel Diagnostic Biomarker of Systemic Lupus Erythematosus
por: Guo, Gangqiang, et al.
Publicado: (2019)

NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation
por: Hu, Yuanbo, et al.
Publicado: (2021)

Dysbiosis in Peripheral Blood Mononuclear Cell Virome Associated With Systemic Lupus Erythematosus
por: Guo, Gangqiang, et al.
Publicado: (2020)

The dynamic RNA modification 5‐methylcytosine and its emerging role as an epitranscriptomic mark
por: Trixl, Lukas, et al.
Publicado: (2018)

5-methylcytosine in RNA: detection, enzymatic formation and biological functions
por: Motorin, Yuri, et al.
Publicado: (2010)

Biologically relevant effects of mRNA amplification on gene expression profiles
por: van Haaften, Rachel IM, et al.
Publicado: (2006)

The cytomegalovirus protein US31 induces inflammation through mono-macrophages in systemic lupus erythematosus by promoting NF-κB2 activation
por: Guo, Gangqiang, et al.
Publicado: (2018)

Functional Profile of Human Cytomegalovirus Genes and Their Associated Diseases: A Review
por: Ye, Lele, et al.
Publicado: (2020)

HNRNPA2B1-mediated m6A modification of TLR4 mRNA promotes progression of multiple myeloma
por: Quan, Lina, et al.
Publicado: (2022)

5-methylcytosine modification of an Epstein–Barr virus noncoding RNA decreases its stability
por: Henry, Belle A., et al.
Publicado: (2020)

Methyltransferase METTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAs
por: Lentini, Jenna M., et al.
Publicado: (2022)

Chemical and enzymatic modifications of 5-methylcytosine at the intersection of DNA damage, repair, and epigenetic reprogramming
por: Baljinnyam, Tuvshintugs, et al.
Publicado: (2022)

5-Methylcytosine (m5C) Modification Patterns and Tumor Immune Infiltration Characteristics in Clear Cell Renal Cell Carcinoma
por: Chen, Can, et al.
Publicado: (2022)

New mRNA modification?
por: Leslie, Mitch
Publicado: (2007)

Correction: HNRNPA2B1-mediated m6A modification of TLR4 mRNA promotes progression of multiple myeloma
por: Jia, Chuiming, et al.
Publicado: (2023)

5-methylcytosine (m(5)C) RNA modification controls the innate immune response to virus infection by regulating type I interferons
por: Zhang, Yuexiu, et al.
Publicado: (2022)

Crystal structures of B-DNA dodecamer containing the epigenetic modifications 5-hydroxymethylcytosine or 5-methylcytosine
por: Renciuk, Daniel, et al.
Publicado: (2013)

Modification-dependent restriction endonuclease, MspJI, flips 5-methylcytosine out of the DNA helix
por: Horton, John R., et al.
Publicado: (2014)

MDR: an integrative DNA N6-methyladenine and N4-methylcytosine modification database for Rosaceae
por: Liu, Zhao-Yu, et al.
Publicado: (2019)

B Cell-Related Circulating MicroRNAs With the Potential Value of Biomarkers in the Differential Diagnosis, and Distinguishment Between the Disease Activity and Lupus Nephritis for Systemic Lupus Erythematosus
por: Zhang, Huidi, et al.
Publicado: (2018)

NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization
por: Su, Jiachun, et al.
Publicado: (2021)

Integrative 5-Methylcytosine Modification Immunologically Reprograms Tumor Microenvironment Characterizations and Phenotypes of Clear Cell Renal Cell Carcinoma
por: Xu, Wenhao, et al.
Publicado: (2021)

5-Methylcytosine (m(5)C) modification in peripheral blood immune cells is a novel non-invasive biomarker for colorectal cancer diagnosis
por: Yin, Haofan, et al.
Publicado: (2022)

Imaging-Based In Situ Analysis of 5-Methylcytosine at Low Repetitive Single Gene Loci with Transcription-Activator-Like Effector Probes
por: Jung, Anne, et al.
Publicado: (2023)

4-Methylcytosine DNA modification is critical for global epigenetic regulation and virulence in the human pathogen Leptospira interrogans
por: Gaultney, Robert A, et al.
Publicado: (2020)

New Insights of Emerging SARS-CoV-2: Epidemiology, Etiology, Clinical Features, Clinical Treatment, and Prevention
por: Guo, Gangqiang, et al.
Publicado: (2020)

Characterizing 5-methylcytosine in the mammalian epitranscriptome
por: Hussain, Shobbir, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_677mf8ipp4l3ot5mc3v0ck6gpt