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Human mortality at extreme age

We use a combination of extreme value statistics, survival analysis and computer-intensive methods to analyse the mortality of Italian and French semi-supercentenarians. After accounting for the effects of the sampling frame, extreme-value modelling leads to the conclusion that constant force of mor...

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Autores principales: Belzile, Léo R., Davison, Anthony C., Rootzén, Holger, Zholud, Dmitrii
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479337/
https://www.ncbi.nlm.nih.gov/pubmed/34631116
http://dx.doi.org/10.1098/rsos.202097
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author Belzile, Léo R.
Davison, Anthony C.
Rootzén, Holger
Zholud, Dmitrii
author_facet Belzile, Léo R.
Davison, Anthony C.
Rootzén, Holger
Zholud, Dmitrii
author_sort Belzile, Léo R.
collection PubMed
description We use a combination of extreme value statistics, survival analysis and computer-intensive methods to analyse the mortality of Italian and French semi-supercentenarians. After accounting for the effects of the sampling frame, extreme-value modelling leads to the conclusion that constant force of mortality beyond 108 years describes the data well and there is no evidence of differences between countries and cohorts. These findings are consistent with use of a Gompertz model and with previous analysis of the International Database on Longevity and suggest that any physical upper bound for the human lifespan is so large that it is unlikely to be approached. Power calculations make it implausible that there is an upper bound below 130 years. There is no evidence of differences in survival between women and men after age 108 in the Italian data and the International Database on Longevity, but survival is lower for men in the French data.
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spelling pubmed-84793372021-10-08 Human mortality at extreme age Belzile, Léo R. Davison, Anthony C. Rootzén, Holger Zholud, Dmitrii R Soc Open Sci Mathematics We use a combination of extreme value statistics, survival analysis and computer-intensive methods to analyse the mortality of Italian and French semi-supercentenarians. After accounting for the effects of the sampling frame, extreme-value modelling leads to the conclusion that constant force of mortality beyond 108 years describes the data well and there is no evidence of differences between countries and cohorts. These findings are consistent with use of a Gompertz model and with previous analysis of the International Database on Longevity and suggest that any physical upper bound for the human lifespan is so large that it is unlikely to be approached. Power calculations make it implausible that there is an upper bound below 130 years. There is no evidence of differences in survival between women and men after age 108 in the Italian data and the International Database on Longevity, but survival is lower for men in the French data. The Royal Society 2021-09-29 /pmc/articles/PMC8479337/ /pubmed/34631116 http://dx.doi.org/10.1098/rsos.202097 Text en © 2021 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Mathematics
Belzile, Léo R.
Davison, Anthony C.
Rootzén, Holger
Zholud, Dmitrii
Human mortality at extreme age
title Human mortality at extreme age
title_full Human mortality at extreme age
title_fullStr Human mortality at extreme age
title_full_unstemmed Human mortality at extreme age
title_short Human mortality at extreme age
title_sort human mortality at extreme age
topic Mathematics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479337/
https://www.ncbi.nlm.nih.gov/pubmed/34631116
http://dx.doi.org/10.1098/rsos.202097
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