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Human mortality at extreme age
We use a combination of extreme value statistics, survival analysis and computer-intensive methods to analyse the mortality of Italian and French semi-supercentenarians. After accounting for the effects of the sampling frame, extreme-value modelling leads to the conclusion that constant force of mor...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479337/ https://www.ncbi.nlm.nih.gov/pubmed/34631116 http://dx.doi.org/10.1098/rsos.202097 |
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author | Belzile, Léo R. Davison, Anthony C. Rootzén, Holger Zholud, Dmitrii |
author_facet | Belzile, Léo R. Davison, Anthony C. Rootzén, Holger Zholud, Dmitrii |
author_sort | Belzile, Léo R. |
collection | PubMed |
description | We use a combination of extreme value statistics, survival analysis and computer-intensive methods to analyse the mortality of Italian and French semi-supercentenarians. After accounting for the effects of the sampling frame, extreme-value modelling leads to the conclusion that constant force of mortality beyond 108 years describes the data well and there is no evidence of differences between countries and cohorts. These findings are consistent with use of a Gompertz model and with previous analysis of the International Database on Longevity and suggest that any physical upper bound for the human lifespan is so large that it is unlikely to be approached. Power calculations make it implausible that there is an upper bound below 130 years. There is no evidence of differences in survival between women and men after age 108 in the Italian data and the International Database on Longevity, but survival is lower for men in the French data. |
format | Online Article Text |
id | pubmed-8479337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-84793372021-10-08 Human mortality at extreme age Belzile, Léo R. Davison, Anthony C. Rootzén, Holger Zholud, Dmitrii R Soc Open Sci Mathematics We use a combination of extreme value statistics, survival analysis and computer-intensive methods to analyse the mortality of Italian and French semi-supercentenarians. After accounting for the effects of the sampling frame, extreme-value modelling leads to the conclusion that constant force of mortality beyond 108 years describes the data well and there is no evidence of differences between countries and cohorts. These findings are consistent with use of a Gompertz model and with previous analysis of the International Database on Longevity and suggest that any physical upper bound for the human lifespan is so large that it is unlikely to be approached. Power calculations make it implausible that there is an upper bound below 130 years. There is no evidence of differences in survival between women and men after age 108 in the Italian data and the International Database on Longevity, but survival is lower for men in the French data. The Royal Society 2021-09-29 /pmc/articles/PMC8479337/ /pubmed/34631116 http://dx.doi.org/10.1098/rsos.202097 Text en © 2021 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Mathematics Belzile, Léo R. Davison, Anthony C. Rootzén, Holger Zholud, Dmitrii Human mortality at extreme age |
title | Human mortality at extreme age |
title_full | Human mortality at extreme age |
title_fullStr | Human mortality at extreme age |
title_full_unstemmed | Human mortality at extreme age |
title_short | Human mortality at extreme age |
title_sort | human mortality at extreme age |
topic | Mathematics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479337/ https://www.ncbi.nlm.nih.gov/pubmed/34631116 http://dx.doi.org/10.1098/rsos.202097 |
work_keys_str_mv | AT belzileleor humanmortalityatextremeage AT davisonanthonyc humanmortalityatextremeage AT rootzenholger humanmortalityatextremeage AT zholuddmitrii humanmortalityatextremeage |