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Central Administration of Hydrogen Sulfide Donor NaHS Reduces Iba1-Positive Cells in the PVN and Attenuates Rodent Angiotensin II Hypertension

Hydrogen sulfide (H(2)S) is a gaseous signaling molecule with neuromodulatory, anti-inflammatory, and anti-hypertensive effects. Here, we investigate whether chronic intracerebroventricular (ICV) infusion of sodium hydrosulfide (NaHS), an H(2)S donor, can alleviate angiotensin II (Ang II)–induced hy...

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Autores principales: Donertas Ayaz, Basak, Oliveira, Aline C., Malphurs, Wendi L., Redler, Ty, de Araujo, Alan Moreira, Sharma, Ravindra K., Sirmagul, Basar, Zubcevic, Jasenka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479468/
https://www.ncbi.nlm.nih.gov/pubmed/34602965
http://dx.doi.org/10.3389/fnins.2021.690919
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author Donertas Ayaz, Basak
Oliveira, Aline C.
Malphurs, Wendi L.
Redler, Ty
de Araujo, Alan Moreira
Sharma, Ravindra K.
Sirmagul, Basar
Zubcevic, Jasenka
author_facet Donertas Ayaz, Basak
Oliveira, Aline C.
Malphurs, Wendi L.
Redler, Ty
de Araujo, Alan Moreira
Sharma, Ravindra K.
Sirmagul, Basar
Zubcevic, Jasenka
author_sort Donertas Ayaz, Basak
collection PubMed
description Hydrogen sulfide (H(2)S) is a gaseous signaling molecule with neuromodulatory, anti-inflammatory, and anti-hypertensive effects. Here, we investigate whether chronic intracerebroventricular (ICV) infusion of sodium hydrosulfide (NaHS), an H(2)S donor, can alleviate angiotensin II (Ang II)–induced hypertension (HTN), improve autonomic function, and impact microglia in the paraventricular nucleus (PVN) of the hypothalamus, a brain region associated with autonomic control of blood pressure (BP) and neuroinflammation in HTN. Chronic delivery of Ang II (200 ng/kg/min, subcutaneous) for 4 weeks produced a typical increase in BP and sympathetic drive and elevated the number of ionized calcium binding adaptor molecule 1–positive (Iba1(+)) cells in the PVN of male, Sprague–Dawley rats. ICV co-infusion of NaHS (at 30 and/or 60 nmol/h) significantly attenuated these effects of Ang II. Ang II also increased the abundance of cecal Deltaproteobacteria and Desulfovibrionales, among others, which was prevented by ICV NaHS co-infusion at 30 and 60 nmol/h. We observed no differences in circulating H(2)S between the groups. Our results suggest that central H(2)S may alleviate rodent HTN independently from circulating H(2)S via effects on autonomic nervous system and PVN microglia.
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spelling pubmed-84794682021-09-30 Central Administration of Hydrogen Sulfide Donor NaHS Reduces Iba1-Positive Cells in the PVN and Attenuates Rodent Angiotensin II Hypertension Donertas Ayaz, Basak Oliveira, Aline C. Malphurs, Wendi L. Redler, Ty de Araujo, Alan Moreira Sharma, Ravindra K. Sirmagul, Basar Zubcevic, Jasenka Front Neurosci Neuroscience Hydrogen sulfide (H(2)S) is a gaseous signaling molecule with neuromodulatory, anti-inflammatory, and anti-hypertensive effects. Here, we investigate whether chronic intracerebroventricular (ICV) infusion of sodium hydrosulfide (NaHS), an H(2)S donor, can alleviate angiotensin II (Ang II)–induced hypertension (HTN), improve autonomic function, and impact microglia in the paraventricular nucleus (PVN) of the hypothalamus, a brain region associated with autonomic control of blood pressure (BP) and neuroinflammation in HTN. Chronic delivery of Ang II (200 ng/kg/min, subcutaneous) for 4 weeks produced a typical increase in BP and sympathetic drive and elevated the number of ionized calcium binding adaptor molecule 1–positive (Iba1(+)) cells in the PVN of male, Sprague–Dawley rats. ICV co-infusion of NaHS (at 30 and/or 60 nmol/h) significantly attenuated these effects of Ang II. Ang II also increased the abundance of cecal Deltaproteobacteria and Desulfovibrionales, among others, which was prevented by ICV NaHS co-infusion at 30 and 60 nmol/h. We observed no differences in circulating H(2)S between the groups. Our results suggest that central H(2)S may alleviate rodent HTN independently from circulating H(2)S via effects on autonomic nervous system and PVN microglia. Frontiers Media S.A. 2021-09-13 /pmc/articles/PMC8479468/ /pubmed/34602965 http://dx.doi.org/10.3389/fnins.2021.690919 Text en Copyright © 2021 Donertas Ayaz, Oliveira, Malphurs, Redler, de Araujo, Sharma, Sirmagul and Zubcevic. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Donertas Ayaz, Basak
Oliveira, Aline C.
Malphurs, Wendi L.
Redler, Ty
de Araujo, Alan Moreira
Sharma, Ravindra K.
Sirmagul, Basar
Zubcevic, Jasenka
Central Administration of Hydrogen Sulfide Donor NaHS Reduces Iba1-Positive Cells in the PVN and Attenuates Rodent Angiotensin II Hypertension
title Central Administration of Hydrogen Sulfide Donor NaHS Reduces Iba1-Positive Cells in the PVN and Attenuates Rodent Angiotensin II Hypertension
title_full Central Administration of Hydrogen Sulfide Donor NaHS Reduces Iba1-Positive Cells in the PVN and Attenuates Rodent Angiotensin II Hypertension
title_fullStr Central Administration of Hydrogen Sulfide Donor NaHS Reduces Iba1-Positive Cells in the PVN and Attenuates Rodent Angiotensin II Hypertension
title_full_unstemmed Central Administration of Hydrogen Sulfide Donor NaHS Reduces Iba1-Positive Cells in the PVN and Attenuates Rodent Angiotensin II Hypertension
title_short Central Administration of Hydrogen Sulfide Donor NaHS Reduces Iba1-Positive Cells in the PVN and Attenuates Rodent Angiotensin II Hypertension
title_sort central administration of hydrogen sulfide donor nahs reduces iba1-positive cells in the pvn and attenuates rodent angiotensin ii hypertension
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479468/
https://www.ncbi.nlm.nih.gov/pubmed/34602965
http://dx.doi.org/10.3389/fnins.2021.690919
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