Fetuin-A, fibroblast growth factor 23 and inflammation in critically ill patients with sepsis

Fetuin-A is a glycoprotein with multifaceted roles, produced mainly in the liver. FGF23 has been reported to control Fetuin-A production in hepatocytes and in the bone. Furthermore, several studies have showed that higher circulating FGF23 levels stimulate inflammatory cytokines in the liver. Howeve...

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Detalles Bibliográficos
Autor principal: Fajol, Abul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479469/
https://www.ncbi.nlm.nih.gov/pubmed/34622191
http://dx.doi.org/10.1016/j.metop.2021.100129
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author Fajol, Abul
author_facet Fajol, Abul
author_sort Fajol, Abul
collection PubMed
description Fetuin-A is a glycoprotein with multifaceted roles, produced mainly in the liver. FGF23 has been reported to control Fetuin-A production in hepatocytes and in the bone. Furthermore, several studies have showed that higher circulating FGF23 levels stimulate inflammatory cytokines in the liver. However, the mechanistic insights linking bilirubin-Fetuin-A, FGF23 and inflammation in patients with sepsis is poorly understood. Therefore, further experimental research is required to link Fetuin, FGF23 and inflammation in the animal models of sepsis to gain further mechanistic insight.
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spelling pubmed-84794692021-10-06 Fetuin-A, fibroblast growth factor 23 and inflammation in critically ill patients with sepsis Fajol, Abul Metabol Open Correspondence Fetuin-A is a glycoprotein with multifaceted roles, produced mainly in the liver. FGF23 has been reported to control Fetuin-A production in hepatocytes and in the bone. Furthermore, several studies have showed that higher circulating FGF23 levels stimulate inflammatory cytokines in the liver. However, the mechanistic insights linking bilirubin-Fetuin-A, FGF23 and inflammation in patients with sepsis is poorly understood. Therefore, further experimental research is required to link Fetuin, FGF23 and inflammation in the animal models of sepsis to gain further mechanistic insight. Elsevier 2021-09-23 /pmc/articles/PMC8479469/ /pubmed/34622191 http://dx.doi.org/10.1016/j.metop.2021.100129 Text en © 2021 The Author https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Correspondence
Fajol, Abul
Fetuin-A, fibroblast growth factor 23 and inflammation in critically ill patients with sepsis
title Fetuin-A, fibroblast growth factor 23 and inflammation in critically ill patients with sepsis
title_full Fetuin-A, fibroblast growth factor 23 and inflammation in critically ill patients with sepsis
title_fullStr Fetuin-A, fibroblast growth factor 23 and inflammation in critically ill patients with sepsis
title_full_unstemmed Fetuin-A, fibroblast growth factor 23 and inflammation in critically ill patients with sepsis
title_short Fetuin-A, fibroblast growth factor 23 and inflammation in critically ill patients with sepsis
title_sort fetuin-a, fibroblast growth factor 23 and inflammation in critically ill patients with sepsis
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479469/
https://www.ncbi.nlm.nih.gov/pubmed/34622191
http://dx.doi.org/10.1016/j.metop.2021.100129
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