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Alkaline intracellular pH (pHi) activates AMPK–mTORC2 signaling to promote cell survival during growth factor limitation

The mechanistic target of rapamycin (mTOR) complex 2 (mTORC2) signaling controls cell metabolism, promotes cell survival, and contributes to tumorigenesis, yet its upstream regulation remains poorly defined. Although considerable evidence supports the prevailing view that amino acids activate mTOR c...

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Detalles Bibliográficos
Autores principales:	Kazyken, D., Lentz, S.I., Fingar, D.C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Accelerated Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479482/ https://www.ncbi.nlm.nih.gov/pubmed/34418433 http://dx.doi.org/10.1016/j.jbc.2021.101100

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