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TRPV4 mediates cell damage induced by hyperphysiological compression and regulates COX2/PGE2 in intervertebral discs

BACKGROUND: Aberrant mechanical loading of the spine causes intervertebral disc (IVD) degeneration and low back pain. Current therapies do not target the mediators of the underlying mechanosensing and mechanotransduction pathways, as these are poorly understood. This study investigated the role of t...

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Detalles Bibliográficos
Autores principales:	Cambria, Elena, Heusser, Sally, Scheuren, Ariane C., Tam, Wai Kit, Karol, Agnieszka A., Hitzl, Wolfgang, Leung, Victor Y., Müller, Ralph, Ferguson, Stephen J., Wuertz‐Kozak, Karin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479521/ https://www.ncbi.nlm.nih.gov/pubmed/34611585 http://dx.doi.org/10.1002/jsp2.1149

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